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39 Chemical Regulation of Breathing

39 Chemical Regulation of Breathing - PSL302 Lecture 39 by...

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Chemical Regulation of Breathing Outline - How is CO 2 and O 2 monitored? - How do chemoreceptors influence ventilation? - How is blood pH regulated? - What happens when these systems fail? Textbook reading: 614-616, 672-674, 679-680 An experiment - Hold your breath. Time how long it takes before you must breathe. - Now take 10 deep breaths. Hold your breath again. Record the time before you must breathe. - Is there a diffce? Why? - You can hold your breath longer after taking 10 deep breaths - When we take deep breaths, we regulate how much O 2 we need & how much CO 2 is in our blood Pulmonary ventilation matches O 2 consumption & CO 2 production - Require certain amt of O 2 to consume to match O 2 uptake at tissues - Want to keep this lvl relatively constant - CO 2 lvls should also be kept constant - Deeper & faster breathing: pulmonary ventilation means [O 2 ] brought in & [CO 2 ] Feedback regulation of breathing - Component of breathing regulated by [O 2 ] & [CO 2 ] - Work thru chemoreceptors : cause ventilation The Metabolic Hyperbola : ventilation arterial PCO 2 - As breathing , more CO 2 blown off ” = PCO 2 - If ventilation PCO 2 - Shape & position of metabolic hyperbola - Determined by rate of pdc° of CO 2 by metabolism Ai d l M Lectu Respirato Airways and lungs alveoli Mus pleura fun Pulmonary ventilation Gas excha alveoli/blo blood/tissu pressures lung how much? properties Respiratory contr Exercise and l P l i l i ure 4 ory system structures scles Pulmonary circulation nctions ange Gas Defense Vocalization ood ues transport Acid/base balance O 2 CO 2 + H 2 0 H + + HCO3 ± ol d High Altitude Pulmonary Ventilation Oxygen stores Po 2 Metabolic Oxygen Consumption Metabolic Carbon Dioxide Production Carbon Dioxide stores Pco 2 Pulmonary Ventilation Gas Ex Ventilation Chemor xchange Pco 2 Po 2 reflexes 30 Alveolar PCO = CO L/min 20 25 2 CO 2 Alveo ation L 15 Ventila 5 10 V 0 10 30 50 20 40 0 Arterial Pco 2 m Production Production
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