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56 Distribution & Msmt of Body Fluids

56 Distribution & Msmt of Body Fluids - PSL302...

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Distribution & Measurement of Body Fluids Lectures Schedule - Distribution & measurement of body fluids - Renal system: basic structure and fxns - Glomerular filtration - Tubular reabsorption - Secretion, excretion and clearance - Antidiuretic hormone - Aldosterone & atrial natriuretic peptide - Role of kidney in acid-base balance - Acid-base, cont’d Outline - Introduction - Body fluids: intake & output - Water & electrolyte balance - Distribution of body fluids - Msmt of body fluids Introduction - 60% of total body weight is made up of water - 50% in obese to 80% in athletes - Diffces in water content also varies with: - Age: newborn (75%) to one-year old (60% - Sex: females have less water b/c more fat & b/c of sex hormones Body fluids: intake & output Daily H 2 O intake & output INTAKE (ml/day) LOSS (ml/day) H 2 O 1000 Skin 500 Food 1200 Lungs 350 Oxidation 300 Feces 150 Urine 1500 TOTAL 2500 TOTAL 2500 Water & electrolyte balance PSL302: Lecture 56, by Perumalla Fri. Mar. 4, 2011 1 of 6
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INTAKE BODY CONTENT [PLASMA] RENAL OUTPUT H 2 O 2 L (0 -20L) 40L 3L 2L Na + 200mM (3-7 g/day) 2000mM 140 mM (125 to 140) <100 >190 200mM H + 70 mM (2 g/day) 3.5 x 10 -3 mM 40 x 10 -6 (28-45 x 10 -6 ) 20N100 x 10 -4 70mM Urea 20 g 10 g 25 mg/100ml (25 N 750) 20 g K + 100mM 4500mM 4.5mM (2.5-5.5) <2 >8 100mM Normokalemia Hyperkalemia Hypokalemia ± Elevated [K + ] outside ± Less diffusion of K + out of the cell ± Elevated RMP (cell partially depolarised) ± Cell more excitable Some causes of Hyperkalemia - Diabetic ketoacidosis:
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