59 Tubular Reabsorption

59 Tubular Reabsorption - PSL302: Lecture 59, by Perumalla!...

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Tubular Reabsorption Outline - Reabsorption - Bulk & regulated reabsorption - Reabsorption in the Proximal Tubule - Reabsorption of Na + - Secondary active transport: glucose & amino acids - Passive transport: urea & transcytosis - Reabsorption in the Loop of Henle - Countercurrent multiplier system - Reabsorption - Materials need to be eliminated - Waste pcts - Excess pcts - Substances body can afford to eliminate - Material body can’t afford to lose - Nutrients - Electrolytes - Other substances - 99% of Fltered ±uid is reabsorbed = 178.5L out of 180L Fltered is reabsorbed - Questions - Why bother to Flter 180L/day & then reabsorb 99% of it? - Why not simply Flter & excrete the 1% that needs to be eliminated? - Answers - Rapidly clear foreign substances from plasma - Bulk fow reabsorption - Takes place in the proximal tubule Regulated reabsorption - Takes place in the later segments oF the nephron - If a substance in the portion of Fltrate that reaches the distal tubule is not needed to maintain homeostasis = passes into urine PSL302: Lecture 59, by Perumalla Mon. Mar. 14, 2011 1 of 6
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400 mOsm 300 mOsm 600 mOsm 900 mOsm 1200 mOsm 300 mOsm Reabsorption in the Proximal Tubule
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59 Tubular Reabsorption - PSL302: Lecture 59, by Perumalla!...

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