61 Antidiuretic Hormone

61 Antidiuretic Hormone - PSL302 Lecture 61 by Perumalla...

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Last week: Clearance of Aminohippuric Acid (PAH) - 80% blood leaves kidneys without being Fltered - No reabsorption of PAH, much is PAH = clearance of PAH is 625mL/min Reabsorption of Glucose - Easily Fltered by glomerulus into renal tubule, so usually not present in urine = normally completely reabsorbed by secondary transport - All reabsorbed, none secreted = clearance of glucose is 0mL/min Summary of Clearance - Determine the renal handling of substance; determine how nephron handles substance Fltered into it - Clearance of inulin/creatinine is calculated and compared to clearance rate of substance being investigated - If Cs < Ci = substance reabsorbed - If Cs > Ci = substance secreted (produced in body) - Diagram - Inulin not reabsorbable, nor is it secreted inulin clearance = 100mL/min (all excreted) - Glucose is reabsorbable in proximal tubule clearance = 0mL/min (none excreted) - Urea partly reabsorbable clearance = 50mL/min (50% excreted, 50% reabsorbed) - Penicillin non-reabsorbable but also secreted from tubule & excreted clearance > Fltration Antidiuretic Hormone Outline - Role of kidneys in water balance - Review of ±uid concentrations in the tubule - Antidiuretic hormone (ADH): responsible for water reabsorption - Mechanism of action of ADH - ²actors controlling ADH release - Renal re±ex - Changes in blood volume Role of kidneys in water balance PSL302: Lecture 61, by Perumalla ²ri., Mar. 18, 2011 1 of 7
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The mug with the hollow handle represents the body The handle represents the kidneys , where the body fluids (plasma) are filtered into the nephron and reabsorbed What happens when there is fluid loss in the mug? ± H 2 O has to be added to the mug from outside to replace lost water. What happens when you add fluid to the mug? results in water leaking out of the handle so as to restore normal volume. - Illustrates the role of kidneys in water balance - Underscores the fact that the kidneys cannot replenish lost water — they can only conserve the current amount in the body - What happens when you add Fuid to mug? - Water leaks out of handle = restore normal V = maintain homeostasis (
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This note was uploaded on 03/27/2012 for the course PSL 301 taught by Professor Mackayfrench during the Winter '12 term at University of Toronto.

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61 Antidiuretic Hormone - PSL302 Lecture 61 by Perumalla...

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