61 Antidiuretic Hormone - PSL302 Lecture 61 by Perumalla...

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Last week: Clearance of Aminohippuric Acid (PAH) - 80% blood leaves kidneys without being filtered - No reabsorption of PAH, much is PAH = clearance of PAH is 625mL/min Reabsorption of Glucose - Easily filtered by glomerulus into renal tubule, so usually not present in urine = normally completely reabsorbed by secondary transport - All reabsorbed, none secreted = clearance of glucose is 0mL/min Summary of Clearance - Determine the renal handling of substance; determine how nephron handles substance filtered into it - Clearance of inulin/creatinine is calculated and compared to clearance rate of substance being investigated - If Cs < Ci = substance reabsorbed - If Cs > Ci = substance secreted (produced in body) - Diagram - Inulin not reabsorbable, nor is it secreted inulin clearance = 100mL/min (all excreted) - Glucose is reabsorbable in proximal tubule clearance = 0mL/min (none excreted) - Urea partly reabsorbable clearance = 50mL/min (50% excreted, 50% reabsorbed) - Penicillin non-reabsorbable but also secreted from tubule & excreted clearance > filtration Antidiuretic Hormone Outline - Role of kidneys in water balance - Review of fluid concentrations in the tubule - Antidiuretic hormone (ADH): responsible for water reabsorption - Mechanism of action of ADH - Factors controlling ADH release - Renal reflex - Changes in blood volume Role of kidneys in water balance PSL302: Lecture 61, by Perumalla Fri., Mar. 18, 2011 1 of 7
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The mug with the hollow handle represents the body The handle represents the kidneys , where the body fluids (plasma) are filtered into the nephron and reabsorbed What happens when there is fluid loss in the mug? ± H 2 O has to be added to the mug from outside to replace lost water. What happens when you add fluid to the mug? ± results in water leaking out of the handle so as to restore normal volume. - Illustrates the role of kidneys in water balance - Underscores the fact that the kidneys cannot replenish lost water — they can only conserve the current amount in the body - What happens when you add fluid to mug?
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