Lecture 25 Mutation and DNA repair I wt bgd_1

Lecture 25 Mutation and DNA repair I wt bgd_1 - Biol142...

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Biol142 Foundations in Modern Biology II Cellular Biology and Genetics Lecture 25 – Monday, April 2 nd , 2012 Mutation and DNA repair I Reading: Klug, Emory 2 nd Ed. Chapter 14 (pages 284 - 289)
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Learning objectives At the end of this lecture, you will be able to: 1) Describe the spontaneous or induced generation of mutations, using tautomeric shifts and deamination as examples. 2)Contrast germline and somatic mutations. 3)Explain the effect of silent, missense, nonsense, and frameshift mutations in a coding DNA sequence on a protein product. 4)Describe the four different types of chromosomal mutations.
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1. Mutations comprise any change in the base- pair sequence of DNA. Mutation is a source of genetic variation and provides the raw material for natural selection. Mutations can occur spontaneously as a result of natural biological and chemical processes, or they can be induced by external factors, such as chemical or radiation. Mutation is also the source of genetic damage that contributes to cell death, genetic diseases, and cancer. Thus, mutations have both benefits and costs.
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Spontaneous mutations are permanent changes, caused by any of several mechanisms: - DNA polymerase sometimes makes errors in replication which can escape being repaired. - Nucleotides occasionally change their structure (called a
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This note was uploaded on 04/02/2012 for the course BIO 142 taught by Professor Escabar during the Spring '08 term at Emory.

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Lecture 25 Mutation and DNA repair I wt bgd_1 - Biol142...

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