Lecture 19 Eukaryotic gene regulation I-1

Lecture 19 Eukaryotic gene regulation I-1 - Gene expression...

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Unformatted text preview: Gene expression changes allow eukaryotic cells to respond to environmental changes and cause distinct cell types to develop. In multicellular eukaryotes, differential gene expression is responsible for creating different cell types, arranging them into tissues, and coordinating their activity. With few exceptions, all cells in an organism have the same genes, but they express them differently. ! For example, both brain and liver cells transcribe l housekeeping z genes that code for enzymes and other molecules essential to the survival of all cells. ! The difference in the production of proteins is due to differential gene expression . ! However, liver cells transcribe some genes for liver-specific proteins, and brain cells transcribe some genes for brain-specific proteins. Biol142 Foundations in Modern Biology II Cellular Biology and Genetics Lecture 19 Monday, March 5 th , 2012 Eukaryotic Gene Regulation I Reading: Freeman, Emory 2 nd Ed. Chapter 18 (pages 319 - 324) Learning objectives At the end of this lecture, you will be able to: 1) Describe the general mechanisms of eukaryotic gene regulation within and outside the nucleus. 2) Test the role of chromatin remodeling in transcriptionally active areas of the genome using the enzyme DNAase . 3) Describe the common promoter and variable regulatory elements of eukaryotic genes. 1. Control of Gene Expression in Eukaryotes Patrick Cafferty Department of Zoology University of British Columbia Overview of gene regulation : Eukaryotic gene expression can be regulated at 3 steps within the nucleus ....
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This note was uploaded on 04/02/2012 for the course BIO 142 taught by Professor Escabar during the Spring '08 term at Emory.

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Lecture 19 Eukaryotic gene regulation I-1 - Gene expression...

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