lecture 11

lecture 11 - Biol142 Foundations in Modern Biology II...

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Biol142 Foundations in Modern Biology II Cellular Biology and Genetics Lecture 11 – Wednesday, February 8 th , 2012 Genomics III. Reading: Freeman, Emory 2 nd Ed. Chapter 20 (pages 367-372)
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Learning objectives At the end of this lecture, you will be able to: 1) Describe the non-coding, repetitive DNA sequences found in eukaryotic genomes, including transposable elements (LINEs) and short tandem repeat sequences. 2) Explain how Minisatellites, or variable number terminal repeats (VNTRs), are used for DNA fingerprinting. 3) Describe how gene duplication can give rise to gene families and how the alternative-splicing hypothesis might account for the small number of genes in the human genome. 4) Use a DNA microarray to identify differences in gene expression in cells subjected to different conditions.
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1. Eukaryotic genomes have several thousand loci called short tandem repeats ( STRs ) . ! Repeated sequences are hypervariable and vary among individuals much more than any other type of sequence. ! STRs are small sequences repeated down the length of a chromosome. There are two types: 1. Microsatellites , or simple sequence repeats , are repeating units of 1 to 5 bases. 2. Minisatellites , or variable number terminal repeats ( VNTRs ), are repeating units of 6 to 500 bases.
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alleles because these highly repetitive stretches may misalign when chromosomes synapse during meiosis. ! Chromosomes produced by unequal crossover contain different numbers of repeats. !
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This note was uploaded on 04/02/2012 for the course BIO 142 taught by Professor Escabar during the Spring '08 term at Emory.

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lecture 11 - Biol142 Foundations in Modern Biology II...

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