2010 Bio 314 Midterm 1

2010 Bio 314 Midterm 1 - Sp10 BIO 314 MT1v0 There are 30...

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Unformatted text preview: Sp10 BIO 314 MT1v0. There are 30 multiple choice questions. Please choose the best answer, and copy your choice to the scantron. Good luck! 1) Our current understandi ng Burkitts lymphoma suggests that the genes associated with antibody (immunoglobulin) generation are frequently amplified the frequency of chromosomal translocations increases as one approaches the equator an antibody- producing cell, which typically only survives for a few weeks, can proliferate indefinitely if myc is overexpressed BL is more likely to occur in an individual whose immune system is overwhelmed by chronic viral and/or parasitic infections. Both C and D are true ) In some tumors, such as pediatric neuroblasto mas, excessive amplificatio n of the myc gene is strongly correlated with poor prognosis. The simplest explanation for this is…. Neuroblastomas with multiple copies of the myc gene are more likely to undergo chromosomal translocation Neuroblastomas with multiple copies of the myc gene are more likely to activate other proto- oncogenes, such as ras Neuroblastomas with multiple copies of the myc gene are more likely to be infected by retroviruses Neuroblastomas with multiple copies of the myc gene probably express enough myc protein to proliferate even in the absence of mitogens Neuroblastomas with multiple copies of the myc gene are more sensitive to chemical carcinogens ) Why are kinase cascades so efficient in signal transduction ? Phosphorylation forces a protein to undergo a predictable conformational change. Changes in conformation are frequently associated with changes in activity, for example an enzyme may become catalytically active when it is phosphorylated by a kinase. Because each kinase molecule is capable of phosphorylating multiple substrate molecules, a signal can be amplified in intensity as it is being transduced. Activation/phosph orylation can be easily reversed by the action of phosphatases. All of the above are correct. ) Retroviruse s... use reverse transcriptase to convert their RNA genome into a double-stranded DNA always transform the host cell. are responsible for chromosomal translocations that contribute to leukemias and lymphomas always insert into the host genome near the myc gene. only infect epithelial cells ) The difference between wild-type ras and activated (oncogenic) ras is that oncogenic ras binds more tightly to its associated GEF (guanine nucleotide exchange factor) oncogenic ras is overexpressed oncogenic ras has lost its GTPase activity oncogenic ras is dimerized even in the absence of ligand binding oncogenic ras has kinase activity ) For the most part, normal epithelial cells are not dividing unless there is a need to replace cells that have been damaged by injury or infection....
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2010 Bio 314 Midterm 1 - Sp10 BIO 314 MT1v0 There are 30...

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