2010 Bio 314 Midterm 2

2010 Bio 314 Midterm 2 - SP10 BIO 314 MT2v0 Choose the one...

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SP10 BIO 314 MT2v0 Choose the one alternative that best completes the statement or answers the question, and copy your selection to the scantron. Please make sure you have answered all 30 questions. Good luck! 1) 1
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Regardin g the APC gene and colon cancer
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APC is a transcription factor that is activated by Wnt signaling
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APC is a kinase that phosphorylate s β -catenin
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APC is a scaffold (adaptor) protein that brings β - catenin and GSK 3 β together.
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APC is the ligand for Wnt receptor   2)
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In respons e to _______ _______ , cyclin D levels increase
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Wnt signaling
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growth factors that engage the Ras pathway
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growth factors that engage the Myc pathway
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mitogenic hormones such as estrogen
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all of the above   3)
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Regardin g Rb, which of the following stateme nts is false ?
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Rb antagonizes oncogenic signaling by inducing senescence
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Rb promotes angiogenesis and metastasis
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Rb promotes differentiation in muscle, bone and fat cells
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Rb blocks cell cycle progression at the R point, which is in late G 1
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Rb represses gene expression by recruiting HDAC to E2F target genes.   4)
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Regardin g tumor suppress ors in general,
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cell fusion studies showed that the tumor suppressors can be dominant to transforming oncogenes.
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tumor suppressors can be negative regulators of cell cycle progression
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tumor suppressors can be negative regulators of cytoplasmic signaling molecules
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tumor suppressors can be negative regulators of transcription factors
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all of the above are correct   5)
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Regardin g HPV, cervical cancer, and the vaccine Gardasil, which of the following is false ?
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Virtually all incidences of cervical cancer are assoicated with HPV infection, but the majority of HPV infections do not result in cervical cancer.
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The vaccine Gardasil provides immunity to 4 high-risk strains (types) of HPV.
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HPV is sexually transmitted, and the incidence of cervical cancer is directly correlated with sexual activity.
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At present, the vaccine is being offered primarily to individuals who have not yet been exposed to HPV.
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Two proteins encoded by the HPV genome are implicated in cervical cancer. One is a cytoplasmic G protein, similar to Ras, and the other is a transcription factor, similar to myc.   6)
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This note was uploaded on 03/28/2012 for the course BIO 314 taught by Professor Erster,s during the Spring '08 term at SUNY Stony Brook.

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2010 Bio 314 Midterm 2 - SP10 BIO 314 MT2v0 Choose the one...

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