2010 Bio 314 Midterm 3

2010 Bio 314 Midterm 3 - Sp10 BIO 314 MT3v0. Please...

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Sp10 BIO 314 MT3v0. Please transfer your answer to all 30 questions to your scantron. Good luck! MULTIPLE CHOICE. Choose the one alternative that best completes the statement or answers the question. 1) 1
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Senesce nt cells fail to respond to mitogeni c signals because
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they no longer express growth factor receptors
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their growth factor receptors are unable to dimerize in response to ligand binding
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their cytoplasmic signalling molecules no longer respond to receptor tyrosine kinase activation
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elevated levels of CDKI's prevent cyclin/CDK activity, and this ensures that the cells will not pass cell cycle checkpoints.   2)
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Regardin g the initiator promoter model, promoter s
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cause mutations in cells that have not been initiated
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are non- specific inducers of cell proliferation
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cause initiation of mutated cells
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are essential for multi-step tumorigenesis .
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None of the above are correct   3)
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A chronic inflamma tory state
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elevates NF κβ expression
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activates I κβ
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suppresses cyclo- oxygenase activity
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interferes with p53- and Rb- mediated pathways
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suppresses TNF α signaling   4)
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The presenc e of dicentric chromos omes in cancer cells is an indicatio n that the cells
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have lost p53 and are approaching senescence
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have lost Rb and are approaching crisis
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have passed senescence and are approaching breakage- fusion-bridge
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have survived crisis and have restored telomerase activity   5)
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Many scientist s support the phenom enon of "obeseo gens", industrial pollutant s and chemical s found in plastics, food packagin g, pesticide s, and cosmetic s, that contribut e to obesity by promotin g adipoge nesis (increas e in number of fat cells) in various organs. This would increase the overall incidenc e of cancer, because dysfuncti onal adipose tissue A )
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mimics a low grade chronic inflammatory state with pro- proliferative and anti- apoptotic signaling
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mimics a hypoxic state, with upregulation of growth factor and growth factor receptor expression that promote angiogenesis and extracellular matrix remodelling
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down- regulates anti- inflammatory molecules such as adiponectin
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up-regulates molecules associated with invasion and metastasis such as PAi-1.
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all of the above   6)
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Regardin g human tumor stem cells, which of the following stateme nts is true?
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This note was uploaded on 03/28/2012 for the course BIO 314 taught by Professor Erster,s during the Spring '08 term at SUNY Stony Brook.

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2010 Bio 314 Midterm 3 - Sp10 BIO 314 MT3v0. Please...

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