2010 Bio 314 Midterm 4

2010 Bio 314 Midterm 4 - Sp10 BIO 314 MT4v0. Please copy...

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Unformatted text preview: Sp10 BIO 314 MT4v0. Please copy your answers to all 30 questions to your scantron. Good luck! 1) 1 Adaptati ons that minimize mutation s in stem cells include all of the following except activating mdr (multiple drug resistance) pump to remove toxins upregulating DNA repair pathways asymmetric DNA strand allocation protective mucus anatomical shielding 2) Regardin g inherited suscepti bility to cancer, which of the following is true? inherited susceptibility to skin cancer can result from defects in nucleotide excision repair inherited susceptibility to breast and ovarian cancer can result from defects in double-strand break repair inherited susceptibility to colon cancer can result from defects in mismatch repair All of the above are true 3) Eat your broccoli! Isothiocy anates ... reverse the silencing of p53 target genes p21 and bax block proteosome- mediated degradation of the inhibitor of NF block oxidative damage to DNA promote the silencing of pro- proliferative genes such as ras and cyclin D inhibit mdm2, so that p53 is stabilized 4) Of the ~22,000 genes in the human genome, _______ ____ are known to be altered by somatic mutation s in human cancers 200-300 approximately 1,000 100-150 20-30 less than 50 5) Regardin g hormone- depende nt (estroge n and testoster one) cancers of the reproduc tive organs, which of the following is false? Treatments include compounds that suppress hormone synthesis, such as aromatase inhibitors They only occur in cells/tissues that synthesize reproductive hormones Treatments include compounds that suppress hormone activity, such as tamoxifen They only occur cells/tissues that express receptors for reproductive hormones 6) The MGMT (methyl guanine methyltra nsferase ) gene is often _______ _ in cancer, and _______ _ of MGMT is associat ed with poor response to chemoth erapy over- expressed...lo ss B) over- expressed...ov erexpression silenced....ove rexpression D) silenced.....los s 7) Watchful waiting vs aggressi ve therapy: which of the following is an argumen t against watchful waiting? Many cancers that are detected in the earliest stages may never progress to life- threatening cancers during the natural lifetime of the individual Chemotherap y may actually only be effective against the less tumorigenic cells in the tumor, and/or the normal cells that are part of the tumor's vasculature (blood vessels) Chemotherap...
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2010 Bio 314 Midterm 4 - Sp10 BIO 314 MT4v0. Please copy...

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