311C S12 L8OL - Membrane Structure and Function Fluid...

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Unformatted text preview: Membrane Structure and Function Fluid Mosaic Model Proposed by Singer and Nicolson (1972) Figure 7.3 Phospholipid bilayer Hydrophilic region of protein Hydrophobic region of protein Membrane Fluidity Lipids Membranes are held together primarily by weak interactions Lateral movement (~10 7 times per second) Flip-flop (~ once per month) Membrane Fluidity Depends on temperature Depends on lipid composition Phospholipid tails Length Saturation Cholesterol Membrane Fluidity Phospholipid hydrocarbon tails Fluid Viscous Membrane Fluidity Cholesterol Cholesterol Membrane Proteins Diverse functions Two general classes of membrane proteins Figure 7.10 Enzymes Signaling molecule Receptor Signal transduction Glyco- protein ATP (a) Transport (b) Enzymatic activity (c) Signal transduction (d) Cell-cell recognition (e) Intercellular joining (f) Attachment to the cytoskeleton and extracellular matrix (ECM) Membrane Proteins Integral membrane proteins At least partly embedded Can be transmembrane Peripheral membrane proteins Not embedded Loosely bound to surface Membrane Carbohydrates Short, branched chains of sugars attached to lipids or proteins Glycolipids Glycoproteins Function: cell-cell recognition Membrane Sidedness Distinct inside and outside faces Lipid composition Membrane carbohydrates Protein orientation Figure 7.12Figure 7....
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311C S12 L8OL - Membrane Structure and Function Fluid...

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