BIO320_HW4_2012 - Name _ BIO320 HW-4 Mitochondrial...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
Name _____________________________________ BIO320 HW-4 (due Tuesday 02/28/2012) Concept: Helix-Wheels. You can use a Helix-Wheel to easily determine the properties of proteins that fold into an alpha- helix. A helix wheel is a graphical representation of the relative positions of amino acids along the alpha-helix seen from the end of the helix. You can learn more about the Helix-Wheel at: http://en.wikipedia.org/wiki/Helical_wheel http://lectures.molgen.mpg.de/Individual/HelicalWheel/index.html http://cti.itc.virginia.edu/~cmg/Demo/wheel/wheel_instructions.html http://cti.itc.virginia.edu/~cmg/Demo/wheel/wheelApp.html For us, a Helix Wheel is an important tool because it allows us to easily determine whether a protein sequence can fold into a Mitochondrial Targeting Signal, or (as we’ll see later) into an alpha-helical coiled coil. Problem 1. Glutamine synthetase is an enzyme involved in ammonia detoxification. In chickens the enzyme is targeted to mitochondria, whereas in humans it is cytosolic. Amphiphathic alpha- helices with positively charged amino acids on one side and hydrophobic amino acids on the
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 03/29/2012 for the course MAN 320F taught by Professor Passovoy during the Spring '08 term at University of Texas at Austin.

Page1 / 3

BIO320_HW4_2012 - Name _ BIO320 HW-4 Mitochondrial...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online