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BIO320_HW4_2012 - Name BIO320 HW-4 Mitochondrial Transport...

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Name _____________________________________ BIO320 HW-4 Mitochondrial Transport & Microtubules (due Tuesday 02/28/2012) Concept: Helix-Wheels. You can use a Helix-Wheel to easily determine the properties of proteins that fold into an alpha- helix. A helix wheel is a graphical representation of the relative positions of amino acids along the alpha-helix seen from the end of the helix. You can learn more about the Helix-Wheel at: http://en.wikipedia.org/wiki/Helical_wheel http://lectures.molgen.mpg.de/Individual/HelicalWheel/index.html http://cti.itc.virginia.edu/~cmg/Demo/wheel/wheel_instructions.html http://cti.itc.virginia.edu/~cmg/Demo/wheel/wheelApp.html For us, a Helix Wheel is an important tool because it allows us to easily determine whether a protein sequence can fold into a Mitochondrial Targeting Signal, or (as we’ll see later) into an alpha-helical coiled coil. Problem 1. Glutamine synthetase is an enzyme involved in ammonia detoxification. In chickens the enzyme is targeted to mitochondria, whereas in humans it is cytosolic. Amphiphathic alpha-
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