Chapter_16_The_Molecular_Basis_of_Inheritance - Molecular...

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Molecular Basis of Inheritance Terms to Know Double helix – form of native DNA, referring to its adjacent polynucleotide strands wound into a spiral Replication fork – a Y-shaped point on a replicating DNA molecule where new strands are growing DNA polymerase – an enzyme that catalyzes the elongation of new DNA at a replication fork by the addition of nucleotides to the existing chain Leading strand – the new continuous complementary DNA strand synthesized along template strand in the mandatory 5’ 3’ direction Lagging strand – a discontinuously synthesized DNA strand that elongates in a direction away from the replication fork DNA ligase – a linking enzyme essential for DNA replication; catalyzes the covalent bonding of the 3’ end of a new DNA fragment to the 5’ end of a growing chain Primer – an already existing RNA chain bound to template DNA to which DNA nucleotides are added during DNA synthesis Primase – an enzyme that joins RNA nucleotides to make the primer Helicase – an enzyme that untwists the double helix at the replication fork, separating the two old strands Mismatch repair - polymerase proofreads the nucleotides and incorrect pairs are removed Nuclease – an enzyme that cuts DNA at segments of the strand that contain damage
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This note was uploaded on 04/01/2012 for the course BIO 141 taught by Professor Dr.cafferty during the Spring '11 term at Emory.

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Chapter_16_The_Molecular_Basis_of_Inheritance - Molecular...

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