Handouts_20-23

Handouts_20-23 - Divide M=Mitosis Prepare to divide Is everything copied properly G2 G0 differentiated Grow double in size Are we big enough G1

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Grow, double in size Are we big enough? G1 G=Gap Copy DNA S=synthesis Prepare to divide Is everything copied properly? G2 Divide M=Mitosis G0 differentiated
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Ub Ub Ub CDK Ub Ub proteosome Cyclin Cyclin Protein 1 fragments protein protein Kinase (ATP) thr ser tyr phosphatase Thr-PO4 Tyr-PO4 Ser-PO4 One family of kinases 2 nd family of kinases
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13-18 hours after Progesterone G2 of Meiosis I G2 5 nl Cytoplasm injection into G2 arrested oocyte No effect M phase: NEBD Arrested in metaphase of meiosis II (36 hours after prgesterone) Fertilization: Mitotic division NEBD maturation Time after fertilization Histone Hi kinase activity MPF activity (injection into immature oocytes) 30 `
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M Time post fertilization proteolysis synthesis Tim Hunt: Nobel prize; Many different cyclin genes in all eucaryotes time Cdc2 (CDK) levels by western blot cycllin MPF activity Slow build-up of cyclin and sudden appearance of MPF Mechanism Compare biochem with changes in Cell cycle advance Slow burning fuse
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This note was uploaded on 03/31/2012 for the course BIS 104 taught by Professor Scholey during the Winter '08 term at UC Davis.

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Handouts_20-23 - Divide M=Mitosis Prepare to divide Is everything copied properly G2 G0 differentiated Grow double in size Are we big enough G1

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