Problem_set_1 - BIS104 Winter 2012 Problem Set I"Due Fri...

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BIS104 Winter 2012 Problem Set I “Due” Fri Jan 20 This problem set will not be collected. However, I will know whether or not you did it by your performance on the exam. 1-3. In studying normal cells, you isolate gene R that normally sequesters and turns off transcription factor E. When active, transcription factor E binds to the promoter of gene A, which encodes a protein that accelerates the cell cycle. 1. You isolate a tumor and find that it has a homozygous null mutation in gene R. In the tumor, transcription factor E is now hyperactive and Gene A is rapidly transcribed. You conclude the following: A. Protein R is sufficient for the inactivation of transcription factor E B. Protein R is necessary for the inactivation of transcription factor E C. Protein R is both necessary and sufficient for the inactivation of transcription factor E 2. If you concluded that protein R is sufficient, describe an experiment to test whether protein R is necessary. If you concluded that protein R is necessary, describe an experiment to test whether protein R is sufficient. (You have a known promoter that you
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