Midterm+1+practice+key

Midterm+1+practice+key - BIS104 Form A Midterm I Feb 4,...

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Unformatted text preview: BIS104 Form A Midterm I Feb 4, 2011 1 1. From your reading in problem set two on the molecular anatomy of a vesicle, which of the following are true? A. A vesicle has only one kind of v-SNARE and only one kind of Rab to bind to a specific membrane. B. More of the surface area of a vesicle is covered by lipids than proteins. C. To purify vesicles, triton-X-100 is used. D. More than half of the Rabs in the genome are on this type of vesicle. E. The uniform vesicles studied were of the COP II variety. 2. You remove a KKVI sequence from the C-terminus of the KDEL receptor. Where would you now find BiP? A. In the ECM B. In the ER C. In the cytoplasm D. In the Golgi E. In the lysosome 3. You can therefore conclude from question #2 that the KKVI sequence is _______ for the localization of BiP to the ER. A. Necessary B. Sufficient C. Necessary and sufficient D. Neither necessary nor sufficient E. Impossible to conclude 4. You isolate digestive enzyme Q that is normally secreted form pancreatic acinar cells. You add a stop transfer signal of 20 hydrophobic amino acids to the middle of the enzyme Q protein sequence. Where will the C-terminus of this new protein be? A. The ER lumen B. The outside the cell C. The cytoplasm D. The cis-Golgi E. It will be degraded 5. Glucose is moved into intestinal epithelial cells against its concentration gradient using __________, and exits the cell into the blood using _____________. A. Glucose ATPase; gated channel B. Na+ symporter; Na+ antiporter C. Na+ antiporter; glucose channel D. facilitator; facilitator E. Na+ symporter; facilitator BIS104 Form A Midterm I Feb 4, 2011 2 6. BiP is normally a component of the ER lumen. You delete the last (C-terminal) four amino acids of BiP. Where would you now predict the majority of BiP to now localize? A. The ER B. Secreted outside the cell C. The Golgi D. The cytosol E. Equally split between one or more of the locations above 7. BiP is normally a component of the ER lumen. You delete the first (N-terminal) eight amino acids of BiP. Where would you now predict the majority of BiP to now localize? A. The ER B. Secreted outside the cell C. The Golgi D. The cytosol E. Equally split between one or more of the locations above 8. BiP is normally a component of the ER lumen. You delete the first eight AND the last four amino acids of BiP. Where would you now predict the majority of BiP to now localize? A. The ER B. Secreted outside the cell C. The Golgi D. The cytosol E. Equally split between one or more of the locations above 9. You isolate a secretion defective mutant strain in yeast that accumulates a great excess of ER to Golgi vesicles. A loss-of-function mutation disrupting which of the following proteins would NOT lead to such a phenotype?...
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This note was uploaded on 03/31/2012 for the course BIS 104 taught by Professor Scholey during the Winter '08 term at UC Davis.

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Midterm+1+practice+key - BIS104 Form A Midterm I Feb 4,...

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