Midterm2_Ckey - Midterm 2 Instructions Form C There are 8...

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Midterm 2 3/9/2012 Form C 1 Instructions: There are 8 pages and 33 questions of equal value in this exam. You get one point or filling out your ID and Form number correctly (warning, 5 students lost this point on the first midterm!) DO NOT OPEN UNTIL INSTRUCTED. The exam will end promptly at 9:50 am. Mark down your test form (A, B, C or D) on the scantron. This is FORM C. If you think there is an error in the exam, notify the proctors. The proctors can’t help you define terms or clarify wording. If you think there are two correct answers, only pick the best one. For each question there is one best answer. Fill out your name and student identification number on the blue Scantron Form with a #2 pencil. Fill in your answers on the scantron form with a #2 pencil. For each question only choose one answer (the best answer) and fill in your selection clearly and completely. If you change an answer, make you sure you erase it completely.
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Midterm 2 3/9/2012 Form C 2 1. Many cancer cells ignore the spindle assembly checkpoint. What will happen to such a cancer cell when it is treated with the drug taxol? A. Microtubules will be depolymerized and the cancer cell will arrest in metaphase B. Microtubules will be depolymerized and the cancer cell will enter anaphase prematurely C. Mad2 will function to inhibit cdc20 in the presence of taxol D. Microtubules will be stabilized and the cancer cell will arrest in metaphase E. Microtubules will be stabilized and the cancer cell will enter anaphase prematurely 2. Which of the following cellular processes is disrupted in a C. elegans animal with a homozygous null mutation in unc-83 ? A. Import of inner nuclear membrane proteins B. Nuclear lamina formation C. Kinesin attachment to the nuclear envelope D. Nuclear migration along microfilaments E. Centrosome attachment to the nuclear envelope 3. E2F is an important component of the machinery to enter the cell cycle in late G1. Mutated E2F can lead to cancer. The mutated form of E2F that leads to cancer is ____. 4. Nucleation of both actin filaments and microtubules is the rate-limiting step of in vitro assays of filament polymerization. You learned in class that ________ directly nucleates actin filaments, while ________ nucleates microtubules in mammalian cells.
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