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Practice+for+final

Practice+for+final - The actual final will have about 60...

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1 The actual final will have about 60 questions Here are some practice questions covering the last week of classes. The rest will look a lot like the midterms. 1. Viagra induces blood flow by relaxing the smooth muscles surrounding blood vessels. This is accomplished __________________. A. by stimulating the nitric oxide transmembrane receptor which increases cAMP. B. by blocking cGMP phospho diesterase. C. by blocking the nitric oxide transmembrane receptor which activates tyrosine kinase activity. D. by inactivating guanylyl cyclase. E. through IP3 signaling which blocks Ca++ release in muscles. 2. Earl Sutherland performed a set of experiments we discussed in class. In brief, he broke open liver cells, and separated soluble supernatant 1 from a membrane pellet. Then he resuspended the membrane, added epinephrine, and spun again to get a supernatant 2. He found that supernatant 2 plus supernatant 1 efficiently stimulated the breakdown of glycogen. What essential signaling component was in Supernatant 1? A. The β -adernergic receptor B. Epinephrine C. cAMP D. Glycogen Phosphorylase Kinase E. A stimulatory heterotrimeric G protein 3. Grb2 is an important player we discussed in the EGF receptor pathway. You have been given a cell line that does not express Grb2 and is therefore unable to respond to EGF. What new protein could you engineer and express to make the cell able to respond and up-regulate a signal in response to EGF?
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