ProblemSet09

ProblemSet09 - BC367, Fall 2011 Problem set #9 Due: Friday,...

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Unformatted text preview: BC367, Fall 2011 Problem set #9 Due: Friday, November 11th (Hand‐in problems must be done on separate pages & short answer questions typed) 1. Hydrogen bonding between A and T (or G and C) bases is usually cited as the principle basis for complementarity and homology. However, other reports suggest that steric patterns between opposing nucleobases are equally (if not more) important. Propose an experiment that would test this theory. 2. In addition to the canonical “B‐form” of DNA, and the less common “A” and “Z” forms, there are other known DNA structures that involve 3 or 4 DNA strands. One theoretical DNA structure, known as “R‐form” DNA, has been proposed to play a role in homologous DNA recombination. Do some brief research into R‐ DNA and describe both the structure and its proposed biological function. 3. Explain why the absorption of ultraviolet light of double‐stranded DNA is less than that of single‐stranded DNA. 4. Discuss why so many coenzymes share an adenosine moiety? 5. You are a researcher in need of a 50‐mer oligonucleotide with 6 successive randomized nucleotides in the middle of an otherwise defined sequence. What is the chemistry associated with chemical oligonucleotide synthesis? How do you incorporate randomization? ...
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