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Class 4 Cholinergics and blockers - Ch 20 21 CHOLINERGICS...

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Ch. 20, 21 CHOLINERGICS And CHOLINERGIC BLOCKERS
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Parasympathetic Nervous System cholinergic receptors [two types] based on location & their action Nicotinic {N} “nicotinic” because stimulated by alkaloid nicotine & Muscarinic {M} because stimulated by alkaloid “muscarine”
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B r a i n S p i n a l C o r d C e n t r a l S o m a t i c [ s k e l e t a l m u s c l e ] P a r a s y m p a t h e t i c [ A C h ] 1 2 a l p h a 1 2 b e t a S y p a t h e t i c [ N E & E P I ] A u t o n o m i c P e r i p h e r a l N e r v o u s   S y s t e m
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Mode of Action of Cholinergics Direct-Acting bind to cholinergic receptors & activate Indirect-Acting work by making more acetylcholine available at receptor by inhibiting enzyme “cholinesterase”
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CHOLINERGICS Direct Acting Indirect-Acting acetylcholine bethanechol carbachol pilocarpine ambenonium demecarium physostigmine echothiophate isoflurophate pyridostigmine edrophonium neostigmine methacholine
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Direct Effect of Cholinergics effects seen when stimulate the parasympathetic nervous system “rest” & “digest” system REMEMBER SLUDGE (or Pee, Poop, Puke) salivation lacrimation urinary incontinence diarrhea gastrointestinal cramps emesis
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Drug Effects-Cholinergics stimulate intestine & bladder increased gastric secretions & GI motility increased urinary frequency stimulate pupil constriction {miosis} decreased intraocular pressure increased salivation & sweating
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Drug effect of Cholinergics cardiovascular effects decreased heart rate & vasodilation respiratory effects constrict & narrow airways at recommended doses the cholinergics primarily effect muscarinic but at high doses nicotinic
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  • Spring '12
  • Buckley
  • Muscarinic acetylcholine receptor, atropine, cholinergic blockers, Cholinergic Blocker Effects, Cholinergics

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