Class 4 Cholinergics and blockers

Class 4 Cholinergics and blockers - Ch. 20, 21 CHOLINERGICS...

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Unformatted text preview: Ch. 20, 21 CHOLINERGICS And CHOLINERGIC BLOCKERS Parasympathetic Nervous System cholinergic receptors [two types] based on location & their action Nicotinic {N} nicotinic because stimulated by alkaloid nicotine & Muscarinic {M} because stimulated by alkaloid muscarine Brain Spinal Cord Central Somatic [skeletal muscle] Parasympathetic [ACh] 1 2 alpha 1 2 beta Sypathetic [NE & EPI] Autonomic Peripheral Nervous System Mode of Action of Cholinergics Direct-Acting bind to cholinergic receptors & activate Indirect-Acting work by making more acetylcholine available at receptor by inhibiting enzyme cholinesterase CHOLINERGICS Direct Acting Indirect-Acting acetylcholine bethanechol carbachol pilocarpine ambenonium demecarium physostigmine echothiophate isoflurophate pyridostigmine edrophonium neostigmine methacholine Direct Effect of Cholinergics effects seen when stimulate the parasympathetic nervous system rest & digest system REMEMBER SLUDGE (or Pee, Poop, Puke) salivation lacrimation urinary incontinence diarrhea gastrointestinal cramps emesis Drug Effects-Cholinergics stimulate intestine & bladder increased gastric secretions & GI motility increased urinary frequency stimulate pupil constriction {miosis} decreased intraocular pressure increased salivation & sweating Drug effect of Cholinergics cardiovascular effects decreased heart rate & vasodilation respiratory effects constrict & narrow airways at recommended doses the cholinergics primarily effect muscarinic but at high doses nicotinic Therapeutic uses of Cholinergics...
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Class 4 Cholinergics and blockers - Ch. 20, 21 CHOLINERGICS...

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