Class 5 Steroids and thyroids

Class 5 Steroids and thyroids - Corticosteroids &...

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Drugs
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Corticosteroids Also called glucocorticoids or steroids Hormones produced by adrenal cortex Affect almost all body organs in  maintaining homeostasis Disease results from inadequate or excess  secretion
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Endogenous Corticosteroids Adrenal cortex produces 30 steroid hormones  divided into Glucocorticoids Mineralcorticoids  These are called CORTICOsteroids not stored manufactured on demand Function immunosuppression anti-inflammatory salt and water regulation (mineralcorticoids) Adrenal sex hormones
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Effects of Steroids on Body Suppression of Immune system Altered metabolism of: Carbohydrates, Protein, Lipids Effects on: Cardiovascular, Nervous, Musculoskeletal, Respiratory,  GI systems Adrenal Sex hormones Androgen and Estrogen Most of effect on body is from androgen Most of sex hormone produced in testes and ovaries
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Mechanism of Action of Steroids Inhibit inflammatory pathways (Immunosuppression) Inhibition of release of arachidonic acid,  prostaglandins, leukotrienes (anti-inflammatory) Inhibit interleukin-1, TNF, cytokines Impair phagocytosis Impair lympthocytes Inhibit tissue repair prolongs erythrocyte life increases protein catabolism redistribute fat from peripheral to central areas
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Uses of Steroids Allergies Connective tissue disorders Skin disorders Endocrine disorders GI disease with inflammatory cause (Crohn’s) Blood disorders with autoimmune causes Hepatic disorders
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Use of Steroids Cancer Neurologic conditions, brain edema,  autoimmune disease (MS, MG) Eye disorders such as optic neuritis, Organ transplantation Nephrotic syndrome Asthma, resp. disorders
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Use of Steroids Rheumatic disorders Shock Preoperative uses
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Class 5 Steroids and thyroids - Corticosteroids &...

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