Class 12 Antidysrhythmics - Antidysrhythmics Antianginals...

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    Chapters 52, 53 Antidysrhythmics Antianginals  
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Cardiac Glycosides-Digoxin  (Lanoxin) Treatment of atrial fibrillation 2 nd  line drug to treat heart failure
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Digoxin Functions positive inotropic action negative chronotropic action negative dromotropic action increase stroke volume
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Digoxin Digoxin Drug interactions Highly toxic with low serum potassium  Glucocorticoids Herbal interactions-St John’s Wort  decreases effectiveness of dig by 25% Antidote for digitalis toxicity- Digoxin Immune Fab-Digibind
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Antianginal Drugs Types of anginal pectoris
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Antianginal Drugs (cont’d) Nonpharmacologic measures to reduce  Angina   Types of antianginals Nitrates Beta-adrenergic blockers Nonselective and selective beta-blockers Side effects/adverse reactions (review)
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Nitrates mainstay of antianginal drug tx multiple routes of administration sublingual, buccal, chewable, tablets, capsules, ointments, patches, inhalable sprays,  & IV’s
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Oral Nitrates Administration of Nitroglycerine SL Should “burn” under tongue Stop all activity! Sit quietly
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Administration of Nitroglycerine  SL Quick onset; relieves pain within 5  minutes Rule of Thumb: If after taking 3 sl nitro 5 minutes apart, and  NO PAIN RELIEF CALL 911
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Cutaneous Administration of  Nitrates (prophylaxis) Apply to clean area (not breasts) Do  not  shave hair (OK to clip) Rotate sites Leave off 12 hrs a day (to reduce  tolerance)
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This note was uploaded on 04/01/2012 for the course BIOL 202 taught by Professor Buckley during the Spring '12 term at University of Massachusetts Boston.

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Class 12 Antidysrhythmics - Antidysrhythmics Antianginals...

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