Class 13 GI drugs - ANTIULCER DRUGS Antiulcer Drugs Gastric...

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ANTIULCER DRUGS
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Antiulcer Drugs Gastric secretions Gastric mucosal barrier (GMB) Peptic ulcers Esophageal ulcer Gastric ulcer Duodenal ulcer Stress ulcer
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Antiulcer Drugs Predisposing factors in peptic ulcer disease Helicobacter pylori (H.pylori) Drugs-NSAIDS, steroids, anti-cancer drugs Genetics Environment Mechanical disturbances Gastroesophageal reflux disease (GERD)
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Nonpharmacologic Measures AVOID: Tobacco Weight loss Avoid hot, spicy, greasy foods. Take NSAIDS, steroids with food Raise head of bed Avoid eating prior to sleeping Avoid alcohol at bedtime
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Drugs classes to Rx Ulcers/GERD Tranquilizers Anticholinergic drugs Antacids Histamine 2 (H 2 ) blockers Proton pump inhibitors Pepsin inhibitor Prostaglandin E 1 analogue
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Tranquilizers Limited effect in treatment Librium sometimes used Anxiolytic Also with ETOH abuse
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Anticholinergics Limited use with ulcer disease Reduce GI motility Delay gastric emptying Take with meals Examples: belladonna, Pro-Banthine SE: dry mouth, tachycardia, urinary retention, constipation
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Antacids Function-neutralize acid Systemic vs Non-systemic antacids Systemic antacids Sodium bicarbonate-MANY SE: excessive sodium, water retention, metabolic alkalosis Calcium carbonate-Causes acid rebound and may cause hypercalcemia
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Nonsystemic antacids Aluminum hydroxide (Amphojel) Calcium carbonate (Tums) Dihydroxyaluminum sodium (Rolaids) Magaldrate (Riopan) Magnesium hydroxide and aluminum hydroxide (Maalox, Mylanta, Gelusil)
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Nursing of the Pt. with Antacids Frequent dosing (up to every 2-3 hrs) 1-3 hrs AFTER meals and HS Chewables followed by water Liquids taken with 2-4 oz water, no more than 4 oz (1/2 cup) Avoid taking with other medications Shake well before using
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SE of Antacids Aluminum constipation hypophosphatemia Magnesium-diarrhea
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This note was uploaded on 04/01/2012 for the course BIOL 202 taught by Professor Buckley during the Spring '12 term at University of Massachusetts Boston.

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Class 13 GI drugs - ANTIULCER DRUGS Antiulcer Drugs Gastric...

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