Lecture 12-posted - HMB265: Human & General Genetics...

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HMB265: Human & General Genetics Lecture 12: Quantitative Genetics Prof. Maria Papaconstantinou
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Lecture Outline Introduction to Quantitative Variation Reading: Griffiths et al ., 10 th edition, Chapter 3 ( emphasis on pages 101-103 ) and Chapter 19 ( emphasis on pages 683-695 ) Continuous variation Additive Inheritance P=G+E
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Phenotypic variation doesn’t always appear “discrete” (i.e. qualitative), but rather continuous. Can genetics explain this kind of variation?
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Many traits seem quantitative in nature Continuous variation Frequently with a normal distribution Q: Can such traits have a genetic basis? Q: Can simple Mendelian genetics explain this?
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Many traits influenced by environment Q: Can such traits have a genetic basis? Q: Can simple Mendelian genetics explain this?
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A trait displaying simple dominance mode of inheritance
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Lecture 12-posted - HMB265: Human & General Genetics...

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