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Lecture 17-1 - HMB265 Human General Genetics Lecture 17...

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HMB265: Human & General Genetics Lecture 17: Transposable Elements Prof. Maria Papaconstantinou
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Lecture Outline Transposable elements in maize Mechanism of action Retrotransposons DNA transposons • Effects of transposons • Laboratory use of transposons • Reading: Griffiths et al ., 10 th edition, Chapter 15 ( emphasis on pages 523-528 and pages 530-546 ).
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Transposition Movement of small segments of DNA called transposable elements from one position to another in the genome Discovered by Barbara McClintock in late 1940s – awarded Nobel Prize in 1983 from Russell (2009) iGenetics
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McClintock’s experiments One strain of corn frequently had break in chromosome 9 Ds element helps cause break Another element Ac required to activate break at Ds locus
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Unusual phenotypes caused by the Ds element
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c-m = c mutable Ds = nonautonomous element Ac = autonomous element • Autonomous elements encode information required for own movement and for movement of nonautonomous elements
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Lecture 17-1 - HMB265 Human General Genetics Lecture 17...

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