Lecture 14 - HMB265: Human & General Genetics Lecture...

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HMB265: Human & General Genetics Lecture 14: Genetic Mapping & Complex Traits I Prof. Maria Papaconstantinou
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Lecture Outline Reading: Griffiths et al ., 10 th edition, Chapter 19 ( emphasis on pages 710-715 ) Quantitative Trait Loci (QTL) Mapping QTL
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How do we determine which genes are involved in controlling the quantitative trait? Dissection of Quantitative Traits
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Dissection of Quantitative Traits A number of genes can have a major effect on phenotype A quantitative effect can be attributed to 2 or more important genes QUANTITATIVE TRAIT LOCI (QTL) Identified using genetic mapping and association of genetic markers with the trait Statistical methods allow the identification of more than one QTL at a time OK, SO HOW IS IT DONE?
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STEP 1: Make an informative cross between individuals that are “inbred” relative to each other, and which differ at the trait(s) of interest
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The power of genetics… Dissecting the basis of tomato fruit size Lycopersicon esculentum cv. Giant Heirloom 1 kg Lycopersicon pimpenellifolium 1 g Anne Frary et al . (2000) Science 289: 85 -88
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Dissecting the basis of tomato fruit size
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Lecture 14 - HMB265: Human & General Genetics Lecture...

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