Lecture 15 - HMB265: Human & General Genetics Lecture...

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HMB265: Human & General Genetics Lecture 15: Genetic Mapping & Complex Traits II Prof. Maria Papaconstantinou
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Lecture Outline Mapping Complex Traits in Plants Mapping Complex Traits in Humans From linkage map locus to candidate gene Haplotype Analysis Genome-Wide Association studies (GWAs) Reading: Griffiths et al ., 10 th edition, Chapter 18 ( emphasis on pages 638-644 ) and Chapter 19 ( emphasis on pages 715-722 )
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The power of genetics… Dissecting the basis of tomato fruit size Lycopersicon esculentum cv. Giant Heirloom 1 kg Lycopersicon pimpenellifolium 1 g Anne Frary et al . (2000) Science 289: 85 -88
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The power of genetics… Dissecting the basis of tomato fruit size Step 1: QTL controlling tomato fruit size were mapped Anne Frary et al . (2000) Science 289: 85 -88
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The power of genetics… Dissecting the basis of tomato fruit size Step 1: QTL controlling tomato fruit size were mapped Anne Frary et al . (2000) Science 289: 85 -88
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Dissecting the basis of tomato fruit size Step 2: Create recombinant inbred lines (RILs) Generated by inbreeding selected individuals, down a lineage Each generation 1-2 siblings within each lineage are inbred, creating a single line of descent from each original F 2 individual For plants, this is known as “single seed descent” Inbred for multiple generations (>8) Recombination at each generation creates a “ladder-like mosaic” of maternal & paternal alleles down length of the chromosome Inbreeding for many generations results in each lineage having a unique mosaic, homozygous for either the maternal or paternal allele at each locus Allows “fine mapping” of traits
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Lecture 15 - HMB265: Human & General Genetics Lecture...

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