BIO220-Slides-Lecture7-W2012

BIO220-Slides-Lecture7-W2012 - 1 Resistance The Evolution...

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Unformatted text preview: 1 Resistance The Evolution of Resistance Malaria: resistance in a host Antibiotics: resistance in a bacterial pathogen HIV: resistance in a viral pathogen 2 Evolution of Resistance in Malaria 7 350-500 million cases 7 1 million deaths 7 Mostly children in sub- Saharan Africa Malaria 7 mosquito-borne 7 fever and chills 7 anemia due to loss of red blood cells Methods of Control 7 drug treatments in humans 7 eradicating the vector (mosquito) 7 decreasing contact between humans and vector Life cycle of Plasmodium Drug Treatment in Humans Malaria Distribution 2011 World Health Organization Malaria Distribution and Reported Drug Restistance World Health Organization Eradicating Mosquitoes I: The larval stage Eradicating Mosquitoes II: The adult stage 10 Evolution of Insecticide Resistance in Mosquitoes 7 Treatment started in 1968 7 Treatment ended in early 1990s 11 Treated Untreated Insecticide use began in 1968, and was stopped in 1990 By 1978 the resistance allele was most common near the sea (and spreading north) After spraying was stopped, its frequency declined rapidly 12...
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BIO220-Slides-Lecture7-W2012 - 1 Resistance The Evolution...

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