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Lecture1 - Lecture 1 Mutation and Mutagens Genotype vs...

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Unformatted text preview: Lecture 1 Mutation and Mutagens Genotype vs. Phenotype Mutations (type, Luria and Delbruck expt ) Mutagens (type, Ames test ) Biological agents/replication error Read: 199-209 Figs: 7.2, 7.4-7.8, 7.10 1 Genotype vs. Phenotype Genotype: genetic make-up (genetic code) Alleles: different variations (genotypes) in a gene of different individuals. Some genes have a single allele- monomorphic; while other genes have multiple alleles- polymorphic WT allele vs. Mutant allele (sometimes less straight forward) Phenotype: the expression of the characteristics (morphology) How does genotype affect phenotype? Alteration of the amount of normal protein produced Changes in different amino acids at different positions have different effects. Proteins have active sites and sites involved in shape or structure. Do genotype always correlate phenotype? Which is more important in determine one’s characteristics? (environment or genotype) 2 3 Mutations: c ha ng e in DNA, he rita b le , m o s tly de va s ta ting , fe w g o o d. The y a lte r pro te in s truc ture a nd a b unda nc e , le a ding to c ha ng e s o f phe no type ....
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Lecture1 - Lecture 1 Mutation and Mutagens Genotype vs...

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