{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

Lecture2 mutation effects

Lecture2 mutation effects - Lecture2:Mutagen(cont)...

Info icon This preview shows pages 1–5. Sign up to view the full content.

View Full Document Right Arrow Icon
Lecture 2: Mutagen (cont.) and Mutational Effects Central dogma (self review: Ch8 page 246-274) A. Transposons and retrotransposons B. T-DNA Biological Mutagens 1 Mutational Effects A. Molecular basis of the mutation protein coding, splicing or regulation B. Genetic/functional basis of the mutation Read: Ch8 page 260-265 and 276-280; Fig. 8.13-18; 8.28-8.31 Read Ch 13 447-453; Fig 13.23, 13.25-28
Image of page 1

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
2 Fig. 13.23 Barbara McClintock
Image of page 2
3 Transposon (transposable element) as a mutagen (1) Retrotransposons (RNA as an intermediate) Copia Drosophila (LTR-type) Ty1 Yeast (LTR-type) LINEs Human (non-LTR-type) SINEs (Alu) Human (non-LTR-type) (2) Transposons Ac/Ds Maize P-element Drosophila Transposon (or TE): DNA segment that can move from one position to another
Image of page 3

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
4 Figure 5-73. The life cycle of a retrovirus. The retrovirus genome consists of an RNA molecule of about 8500 nucleotides; two such molecules are packaged into each viral particle. The enzyme reverse transcriptase first makes a DNA copy of the viral RNA molecule and then a second DNA strand, generating a double-stranded DNA copy of the RNA genome. The integration of this DNA double helix into the host chromosome is then catalyzed by a virus-encoded integrase enzyme. This integration is required for
Image of page 4
Image of page 5
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern