Lecture2 mutation effects

Lecture2 mutation effects -...

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Lecture 2: Mutagen (cont.) and Mutational Effects Central dogma (self review: Ch8 page 246-274) A. Transposons and retrotransposons B. T-DNA Biological Mutagens 1 Mutational Effects A. Molecular basis of the mutation protein coding, splicing or regulation B. Genetic/functional basis of the mutation Read: Ch8 page 260-265 and 276-280; Fig. 8.13-18; 8.28-8.31 Read Ch 13 447-453; Fig 13.23, 13.25-28
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2 Fig. 13.23 Barbara McClintock
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3 Transposon (transposable element) as a mutagen (1) Retrotransposons (RNA as an intermediate) Copia Drosophila (LTR-type) Ty1 Yeast (LTR-type) LINEs Human (non-LTR-type) SINEs (Alu) Human (non-LTR-type) (2) Transposons Ac/Ds Maize P-element Drosophila Transposon (or TE): DNA segment that can move from one position to another
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4 Figure 5-73. The life cycle of a retrovirus. The retrovirus genome consists of an RNA molecule of about 8500 nucleotides; two such molecules are packaged into each viral particle. The enzyme reverse transcriptase first makes a DNA copy of the viral RNA molecule and then a second DNA strand, generating a double-stranded DNA copy of the RNA genome. The integration of this DNA double helix into the host chromosome is
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This note was uploaded on 04/03/2012 for the course BSCI 410 taught by Professor Staff during the Spring '08 term at Maryland.

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Lecture2 mutation effects -...

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