Lecture4 genetic interactions

Lecture4 genetic interactions - Lecture4:Geneticinteractions

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1 Lecture 4: Genetic interactions Relationship between mutations in different genes Epistasis  in a biochemical pathway Epistasis in a regulatory pathway Additive  interactions Synergistic  interactions Suppressions   Fig. 7.23 (p224-226) Fig. 8.32 (p281); 8.5-8.6 (250-252)
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2 What is epistasis? A gene interaction in which the effects of an allele at one gene hide the  effects of alleles at another gene Epistasis analyses
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3 C2 red CHI F3H A1 A2 BZ1 BZ2 GLUCOSIDE ANTHOCYANINS Mt1, Mt2 DIHYDROFLAVONOL FLAVAN-3,4-DIOL FLAVANONE CHALCONE Peonidin-3-(p-coumaroyl)- rutinoside-5-gluciside A. Flavonoid biosynthetic pathway in maize bronze 2
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WT: Red Mutations in c2, a1, a2: Colorless Mutations in bz1, bz2: bronze Double mutants C2/a1: colourless-but uninformative bz1/a1: colorless-a1 comes before bz1 bz2/a1: colorless-a1 comes before bz2 For biosynthetic pathways, the phenotype of the earlier gene in the pathway shows in the double mutant. ie. the earlier-step mutant is epistatic to the late-step mutant Determine relationship between a1 and c2 by feeding experiment: add flavanone (naringenin): c2+naringenin = red a1+naringenin = colorless
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5 Fig. 7.20 Biochemical Pathways Fig. 7.23
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Lecture4 genetic interactions - Lecture4:Geneticinteractions

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