Lecture10 insights genome seq

Lecture10 insights genome seq - LECTURE 10: INSIGHTS FROM...

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1 LECTURE 10: INSIGHTS FROM GENOME SEQUENCING Bioinformatic continued: OMIM (Online Mendelian Inheritance in Man ) Genome sequencing summary C-value paradox What makes each organism unique? Comparative genomics (synteny) Ortholog vs paralog Insights from human genome Lateral gene transfer Re a d C ha pte r 10  (p341-348) Fig . 10.7-9 a nd Fig .  10.12-14
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2 Table 10.2 The information content of an organism's genome is not necessarily proportional to its complexity
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3 The C-value paradox The bigger a genome, the more repetitive DNA Arabidopsis:   1X 10 5 kb (14%) Tomato: 1X 10 6 kb (15-20%); Mung Bean: 4.5X10 5 kb (30%) Pea: 4.1X 10 6 kb (70%) Wheat, Corn 10 7 kb (60-80%) -Adh1 gene in maize:
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Why sequence the genomes of model organisms? Identify genes and gene function in related organisms Allow prediction of gene function based on domain homology Facilitate genome sequencing of related organisms Genome sequence studies affirm evolution from a common ancestor Provide abundant molecular markers used for disease diagnosis, etc. Facilitate gene mapping and gene identification 4
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Comparison of total gene numbers in sequenced genomes: Near constant number of genes in all genomes irrespective of genome sizes 25,000 Arabidopsis  20-30,000 human  19,099 in C. elegans 13,600 in Drosophila Smaller than originally expected Human genome thought to have 100,000 genes Now thought to be closer to 20,000–30,000 genes What makes each organism unique? What creates the diversity?
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This note was uploaded on 04/03/2012 for the course BSCI 410 taught by Professor Staff during the Spring '08 term at Maryland.

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Lecture10 insights genome seq - LECTURE 10: INSIGHTS FROM...

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