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Lecture 4 Ecoli part - Enterohemorrhagic E coli(EHEC The disease Low Infective dose 100 cell s Incubati on peri od 3-4 days Illness du rati on 3-7

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FST104 January 18, 2012 The disease Low Infective dose: 100 cells Incubation period: 3-4 days Illness duration: 3-7 days, sometimes much longer Symptoms: copious bloody, mucosal discharge caveat: sometimes non-bloody diarrhea No fever Enterohemorrhagic E. coli (EHEC) Very serious for children Toxic for kidneys – 1/3rd cases have abnormal kidney function years later, may require long-term dialysis 2 major diseases: 1. Hemorrhagic colitis (bloody stools) Diarrhea caused by EHEC with dysentery- like symptoms Enterohemorrhagic E. coli (EHEC) continued 2. Hemolytic uremic syndrome (HUS) 2-7% of the cases kidneys become blocked with damaged red blood cells Hemolytic anemia Acute renal failure Most infamous EHEC: E. coli O157:H7 Enterohemorrhagic E. coli (EHEC) continued First EHEC known, identified in 1982 Associated with undercooked beef and fresh produce Serious disease – resulted in food safety regulations O157:H7 stands for the serotype Cattle are known a known reservoir of the pathogen
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Serotype or Serovar Subdivision of a species based on antigenic differences Subspecies differences among pathogens O antigens Sugar side-chains of LPS H antigens Flagellin present as part of the flagellar structure K antigens Capsular or extracellular polysaccharides Produce a secreted Cytotoxin (Verotoxin)
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Lecture 4 Ecoli part - Enterohemorrhagic E coli(EHEC The disease Low Infective dose 100 cell s Incubati on peri od 3-4 days Illness du rati on 3-7

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