Lecture+7+Campylobacter+and+Sporeformers+_color_

Lecture+7+Campylobacter+and+Sporeformers+_color_ - January...

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January 25, 2012 FST104 Common cause of diarrheal illness due to bacterial infection in the US Campylobacter jejuni Causes illness in 400-500 million people per year, or 5-14% of diarrhea world-wide Characteristic corkscrew-like movement Campylobacteraceae family in the Proteobacteria phylum
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Until the mid-1970s, C. jejuni infections were attributed to viruses C. jejuni is difficult to grow in the lab Special enrichment conditions are required Microaerophile 5% O 2 and 10% CO 2 for growth (Air is 20% O 2 and 0.04% CO 2 ) Poor competitor compared with other intestinal or food-associated bacteria for growth in laboratory culture medium http://www.youtube.com/watch?v=E8YroyRCwSc
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Variable symptoms: Severe abdominal cramping followed by diarrhea Bloody Diarrhea Nausea and vomiting Symptoms of campylobacteriosis The disease Infective dose: low (~ 500 cells) Incubation period: 2-9 days Illness duration 1-4 days Minor relapses reported in 15-25% of patients Disease rarely fatal Influenza-like symptoms: fever, headaches and dizziness Guillain Barré Syndrome (GBS) Side-effects of Campylobacter infection USA: 1 out of 1000 cases of Campylobacter infection Rapid onset of paralysis of the legs, arms, breathing muscles and face Autoimmune reaction: immune response to foreign antigens (such as infectious agents) that is mis-targeted at host peripheral nerve tissues A leading cause of non-trauma-induced paralysis in the world
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Lecture+7+Campylobacter+and+Sporeformers+_color_ - January...

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