Lecture+8+Bacillus+and+Clostridium+_color_

Lecture+8+Bacillus+and+Clostridium+_color_ - FST104 January...

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FST104 January 27, 2012 The disease: two distinct syndromes Emetic disease Gastroenteritis Rare to have both at once Gastroenteritis Emetic disease Minimum number of cells for making toxin in right amounts 10 6 -10 7 cells same Incubation period 8-16 hrs 2-6 hrs Symptoms Typical gastroenteritis Vomiting Illness duration 8-12 hrs 4-10 hrs Types of food most commonly implicated Protein-rich foods Starch-rich foods Illness caused by B. cereus
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Heat-stable and pH-stable Resistant to proteolysis B. cereus emetic toxin Made by a non-ribosomal synthetase Mechanism for inducing vomiting is not fully understood Cereulide (emetic toxin) Cyclic dodecadepsipeptide with molecular mass 1.2 kDa and the structure: [D-O-Leu-D-Ala-D-O-Val-D- Val]3 B. cereus enterotoxins Enterotoxins cause Gastroenteritis 3 enterotoxins are known Cause intestinal fluid secretion by several mechanisms (pore formation and activation of adenylate cyclase enzymes) Hbl Hemolytic enterotoxin Nhe Non-hemolytic enterotoxin CytK Cytotoxin K All are heat labile toxins
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Prevent soil contamination in foods B. cereus control Do not hold foods at warm temperatures for long periods of time (e.g. >12 hrs for “steamed rice”) Refrigeration after cooking will solve the problem only if toxin was not already formed In August 2003, five children of a family became sick after eating pasta
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This document was uploaded on 04/03/2012.

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Lecture+8+Bacillus+and+Clostridium+_color_ - FST104 January...

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