Lecture+9+Clostridium+Staph+_color_

Lecture+9+Clostridium+Staph+_color_ - FST104 January 30,...

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FST104 January 30, 2012 Clostridium botulinum 3 Types of botulism Adult botulism Infant botulism Wound botulism All caused by a NEUROTOXIN C. botulinum is a Biosafety level 3 microbe
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Blocks release of acetylcholine, a neurotransmitter, from the ending of the motor nerve Mechanism of the botulinum A zinc metalloprotease C. botulinum neurotoxin The classic symptoms of botulism blurred vision, dizziness, and difficulty speaking, followed by gradual paralysis, ultimately, respiratory paralysis Anti-toxin (antibodies) can inactivate toxin molecules which are not bound to synapses. It will not reverse the effect of bound toxin Botulism survivors may be partially paralyzed for life
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Adult food-borne botulism Food can have sufficient toxin to kill many people without the slightest odor or taste indicating bacterial growth Disease result of ingesting the toxin ( Intoxication ) Dose: a few nanograms of toxin Incubation period: 48hrs On April 3, 2011 , a Georgia resident, aged 41 years, tasted potato soup purchased from a local grocer, noted a sour taste, and discarded the remainder. The soup, stored in a plastic container labeled "keep refrigerated" in letters 1/8
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Lecture+9+Clostridium+Staph+_color_ - FST104 January 30,...

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