BIO 325L Lecture 7 - This week in lab 1 Peer review You MUST have copies of your paper ready at the start of class Print early Be constructive be

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This week in lab Peer review You MUST have copies of your paper ready at the start of class Print early! Be constructive, be polite, but be honest Discuss strengths of each paper with people at your table What strategies could you adopt for your own paper? 1
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What do you need to turn in? This week (3/6&7) STR results homework Bring copies of paper to lab for peer review Tonight (3/5): 6pm – 8pm Next week (3/12): Spring break! Week of 3/19 Homework: Fly lab analysis (Chi-square tests) First version of essay for grade 2
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Today in lecture STR notables and statistics problem Determining crossing over in Drosophila 3
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Thinking about DNA evidence Is someone automatically guilty if their DNA is found at a crime scene? Is someone innocent if their DNA is not found at the crime scene? How certain can we be of a DNA match? 4
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Why the doublets? The TH01 locus showed two bands for each allele The conditions of the gel and the nature of DNA Samples were boiled and the gel was run under denaturing conditions Affect on a DNA molecule? How are the two strands of a DNA molecule different? Repeat is “AATG” Gel was very long 5
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Chi-square problem How to handle an expected value of 0 (O-E)2/E … you can’t divide by zero Maybe the statistical test is not appropriate? Chi-square tests need a minimum score count “Ignore” the category The flies DO contribute to the total Ex. 75:10:15 for an “expected” 3:0:1 ratio For expected values use 75:25, not 67.5:22.5 Differences of 0 and 4, not 0.83 and 2.5 6
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Crossing over Offspring phenotypes can be used to calculate cross over rates/map unit distances Sordaria Phenotype patterns of asci Different patterns between crossed/not crossed Flys Slightly more complicated Diploid offspring All meiotic outcomes not represented in a set Depends on probabilities of offspring 7
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Figuring out map units Map units are measures of the frequencies of crossing over Frequencies Describe the probability of an outcome
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This note was uploaded on 04/02/2012 for the course BIO 325L taught by Professor Franks during the Spring '08 term at University of Texas at Austin.

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BIO 325L Lecture 7 - This week in lab 1 Peer review You MUST have copies of your paper ready at the start of class Print early Be constructive be

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