Allie+Rheology+Lecture+1_23_12

Allie+Rheology+Lecture+1_23_12 - 1/26/2012 BLOOD...

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1/26/2012 1 BLOOD COMPOSITION Whole blood consists of formed/cellular elements and plasma Formed elements : Red blood cells (RBCs) or erythrocytes White blood cells (WBCs) or leukocytes Platelets Plasma consists of: Water (92%) Plasma proteins (7%) Other solutes (1%) Hematocrit (H) is the percentage of whole blood occupied by cellular elements FORMED ELEMENTS Cellular components of blood RBC – 95% of cellular component WBC – ~0.1% of cellular component Platelets – 4.9% of cellular component
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1/26/2012 2 RED CELL BASICS In adult males 1 μl of whole blood contains 4.5-6.3 billion RBCs Shape : Biconcave disk-thin central region and thick outer margin. Why? Composition : Only organelles related to transport of respiratory gases Hemoglobin (Hb) accounts for 95% of the cell’s intracellular proteins Function : Deliver oxygen Production : No nuclei or ribosomes, so they cannot divide or produce their own proteins. Life span ~120 days RBC formation ( erythropoiesis ) occurs in red bone marrow RED CELL BASICS Texas Tech Univ Pathology Dept. NORMAL RBCs ROULEAUX FORMATION SICKLE CELL Diameter 8.1 ± 0.4 m m Greatest thickness 2.7 ± 0.2 m m Least thickness 1.0 ± 0.3 m m Surface area 138 ± 17 m m 2 Volume 95 ± 17 m m 3
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1/26/2012 3 WHITE BLOOD CELL BASICS In adults 1 μl of whole blood contains 6-9 thousand WBCs Shape : Divided to granulocytes and agranulocytes Composition : They do have a nucleus They contain vesicles and lysosomes Function : Defend the body against invasion by pathogens Remove toxins, waste, abnormal or damaged cells Production : They survive from days (N) to months or years (L) Produced in the bone marrow Also produced in lymphoid tissues Neutrophil (50-70%) Eosinophil (2-4%) Basophil (<1%) Monocyte (2-8%) Lymphocyte (20-30%) PLATELET BASICS
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Allie+Rheology+Lecture+1_23_12 - 1/26/2012 BLOOD...

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