BIM+106+Project - BIM 106 Project ...

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Unformatted text preview: BIM 106 Project Due March 16, 2012 Drugs can be delivered in a variety of routes, ranging from pills, ointments, crèmes, injections, eyedrops, and many others. Drug delivery through the skin is a promising strategy given the size of the organ and the capacity to deliver drugs over a sustained period using transdermal drug delivery devices. Drugs diffuse across the multiple skin layers until they reach a capillary, then after diffusion across the capillary wall, the drug enters the circulatory system for systemic distribution. In order to test the efficacy of these systems, porcine (pig) or cadaveric skin may be used, yet they each suffer from limitations related to differences in species or the use of dead tissue. Therefore, the development of effective model systems is a critical strategy to improve the relevance of Figure 1. A tissue ­engineered skin in vitro testing while not consuming valuable tissues for transplantation. equivalent. Image courtesy of Medscape. You are head of R&D in a small start ­up company, and you (along with your group of top notch UCD bioengineers, no more than 4 people per group) would like to develop a tissue engineered skin equivalent to characterize the delivery of a drug (you have some latitude here to select) through the skin. You would like to examine the impact of changing the skin equivalent’s properties on steady ­state drug delivery through the system. Using your knowledge of mass transport and necessary details related to the drug, predict the impact of porosity and diffusion coefficient on the concentration profile across the membrane. You will need to find your relevant data independently (e.g., molecule size, reasonable partition coefficients, approximate drug concentrations, etc.). You should plan on varying at least 4 parameters of your system such as dose, porosity, partition coefficient, and others. Generate your graphs (which must be included in your report) using any computational package at your disposal (Matlab, Excel, Fortran). You must also compare the results of your model with published evidence of the same drug’s transport through tissue engineered skin or some other skin equivalent (finding these data will likely drive your selection of a drug). Provide about 1 page of background information on the drug and its uses, as well as the need for skin equivalents as model systems for drug delivery in vivo. Be sure to reference your sources (minimum of 5) and cite them within your report (Note: Wikipedia IS NOT an accepted reference). Clearly state your assumptions in this analysis. Provide a description of your equations (be sure to put them in), any particularly pertinent derivations, and label all variables clearly (i.e., define each variable). If using Matlab or Fortran, you must include your code at the end of your document. Discuss your results in approximately one page, making sure to comment on the validity of your data and your assumptions, the benefits of using this system versus another, and potential reasons this system (and analysis) may break down. Lastly, describe at least 2 applications of human skin equivalents and how their application may benefit human or animal health. In addition to this report, each group will upload a video (approximately 4 ­5 min in duration) that describes their findings to elementary students (4th graders). These videos can be made using any device you have at your disposal (camera, iChat, iPhone, etc.), provided you upload a file that can be universally viewed. I prefer that you provide the video to me, either through Smartsite or other medium. If absolutely necessary, you can also upload your video to your website or other resources, provided it is easily accessed. Here’s your chance to be creative, use analogies, demonstrations, or whatever gets your point across! Creativity counts! Formatting details: Font size should be Arial 12, 1” margins, single spaced. Include a title page with the names of all participants. Everything MUST BE typed (no handwritten equations or hand ­graphed data). Both your written document and file (Matlab or Fortran code, Excel spreadsheet, Mathcad worksheet) should be uploaded to SmartSite through the Assignments link (Project) before 5 pm on Friday, March 16, 2012. Only one participant from each group need upload the document. Your grade for this exercise will be derived from both accuracy and creativity. You will also be evaluated by your teammates with an evaluation that will be submitted by the last day of class. This evaluation will be available by SmartSite, and you will complete the evaluation and return it electronically. ...
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