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Seizure disorders HANDOUT

Seizure disorders HANDOUT - Physiology 601 Oct 2011 Seizure...

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Physiology 601- Oct 2011 Seizure Disorders - Epilepsy Jim McAuley, R.Ph, Ph.D. Associate Professor of Pharmacy Practice and Neurology [email protected]
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Physiology 601- Oct 2011 My Practice Site Outpatient Epilepsy Clinic Adult Population Tertiary Care Referral Center Interdisciplinary Approach Specialty-Trained Neurologists – Epileptologists Certified Nurse Practitioner Clinical Pharmacist – Students Patient care, teaching & research
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Physiology 601- Oct 2011 Plan for This Morning Overview of Epilepsy Pathophysiology Clinical presentation – Video – Neuroanatomy Drug Targets – Neurotransmitter systems Example of Clinical Research
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Physiology 601- Oct 2011 Definitions Seizures – Sudden, uncontrollable electrical discharges in normal brain activity Epilepsy – Recurrent unprovoked seizures at least 2 seizures for diagnosis
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Physiology 601- Oct 2011 Overview of Disease Prevalence – 1 to 2% of Population – Men and Women equally Incidence – Highest in very young and very old U-Shaped Curve Prognosis – Seizure-freedom should be the ultimate goal optimized regimen
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Physiology 601- Oct 2011 Underlying Mechanisms Balance is Important Excitatory Control Glutamate receptors (NMDA, non-NMDA) Excess is a problem Inhibitory Control • GABA A - major inhibitory neurotransmitter Lacking is a problem Manipulate both in therapy
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Physiology 601- Oct 2011 Seizure Types Classification PARTIAL GENERALIZED Simple Complex Absence Atonic Tonic Myoclonic Tonic Clonic
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Physiology 601- Oct 2011 Patient Presentation Anatomy – Lobe involved – Symptoms Various Clinical Presentations Drop attacks Numbness Visual disturbs Oral automatisms
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