Seizure disorders HANDOUT

Seizure disorders HANDOUT - Physiology 601- Oct 2011...

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Unformatted text preview: Physiology 601- Oct 2011 Seizure Disorders - Epilepsy Seizure Disorders - Epilepsy Jim McAuley, R.Ph, Ph.D. Associate Professor of Pharmacy Practice and Neurology McAuley.5@osu.edu Physiology 601- Oct 2011 My Practice Site O u t p a t i e n t E p i l e p s y C l i n i c Adult Population T e r t i a r y C a r e R e f e r r a l C e n t e r I n t e r d i s c i p l i n a r y A p p r o a c h Specialty-T rained Neurol ogists Epileptologists Certified Nurse Practi tioner Clinical Pharmaci st Students P a t i e n t c a r e , t e a c h i n g & r e s e a r c h Physiology 601- Oct 2011 Plan for This Morning O v e r v i e w o f E p i l e p s y P a t h o p h y s i o l o g y C l i n i c a l p r e s e n t a t i o n Video Neuroanatomy D r u g T a r g e t s Neurotransmitter systems E x a m p l e o f C l i n i c a l R e s e a r c h Physiology 601- Oct 2011 Definitions S e i z u r e s Sudden, uncontrollable electrical discharges in normal brain activity E p i l e p s y Recurrent unprovoked seizures at least 2 seizures for diagnosis Physiology 601- Oct 2011 Overview of Disease P r e v a l e n c e 1 to 2% of Population Men and Women equally I n c i d e n c e Highest in very young and very old U-Shaped Curve P r o g n o s i s Seizure-freedom should be the ultimate goal optimized regimen Physiology 601- Oct 2011 Underlying Mechanisms Balance is Important E x c i t a t o r y C o n t r o l Glutamate receptors (NMDA, non-NMDA) Excess is a problem I n h i b i t o r y C o n t r o l GABA A- major inhibitory neurotransmitter Lacking is a problem M a n i p u l a t e b o t h i n t h e r a p y Physiology 601- Oct 2011 Seizure Types Classification PARTIAL GENERALIZED Simple Complex Absence Atonic Tonic Myoclonic Tonic Clonic Physiology 601- Oct 2011...
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This note was uploaded on 04/05/2012 for the course PHYS 601 taught by Professor Jenlucas during the Fall '11 term at Ohio State.

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Seizure disorders HANDOUT - Physiology 601- Oct 2011...

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