09-14 gene synthesis and repair

09-14 gene synthesis and repair - DNA Synthesis and Repair...

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DNA Synthesis and Repair B U
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Experiments Showing DNA was the Hereditary Material of Genes Frederick Griffith experiment (1928) Rough (R) strain of Streptococcus pneumoniae is not virulent Smooth (S) strain is virulent Freeman,  Fig. 14.1
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Experiments Showing DNA was the Hereditary Material of Genes QUESTION: When R and S strains infect the same host, how do they interact? HYPOTHESIS: One strain may be altered by co-infection with a different strain NULL HYPOTHESIS: One strain will not be altered by co- infection with a different strain Freeman,  Fig. 14.2
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Experiments Showing DNA was the Hereditary Material Oswald Avery et al. experiment (1940s) How were Griffith’s R strains “transformed” into S strains? OBJECTIVE: discover whether it was DNA, RNA, or protein Freeman, Fig. 14.3
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Experiments Showing DNA was the Hereditary Material of Genes Alfred Hershey-Martha Chase experiment Are genes made of protein or DNA? Use T2 bacteriophage (bacterial virus) Freeman, Fig. 14.4a Freeman,  Fig. 14.5
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How Does DNA Do It Two crucial questions were raised by the finding that DNA is the hereditary material: (1) How did the simple primary and secondary structure of DNA hold the information required to make life possible? (2) How is DNA copied so that genetic information is faithfully passed from one cell to another during growth and from parents to offspring during reproduction?
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The following diagram illustrates a segment of DNA. The green color represents normal nucleotides.
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09-14 gene synthesis and repair - DNA Synthesis and Repair...

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