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BILD2_Lect_2_14_12

BILD2_Lect_2_14_12 - tumor(carcinoma Larger benign...

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Figure 12.20 Glandular tissue Tumor Lymph vessel Blood vessel Cancer cell Metastatic tumor A tumor grows from a single cancer cell. Cancer cells invade neighboring tissue. Cancer cells spread through lymph and blood vessels to other parts of the body. Cancer cells may survive and establish a new tumor in another part of the body. 4 3 2 1 Illustration of ideas presented in lecture regarding process of metastasis Figure 18.25 Colon Normal colon epithelial cells Loss of tumor- suppressor gene APC (or other) 1 2 3 4 5 Colon wall Small benign growth (polyp) Activation of ras oncogene Loss of tumor- suppressor gene DCC Loss of tumor- suppressor gene p53 Additional mutations Malignant
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Unformatted text preview: tumor (carcinoma) Larger benign growth (adenoma) Illustration of ideas presented in lecture regarding multi-hit model for cancer All of the following are hallmarks of cancer except: A. infectivity towards other cells B. lack of responsiveness to cell growth signals C. resistance to programmed cell death D. sustained angiogenesis E. limitless replication potential All of the following are are likely to contribute to the development of cancer except: A. a defect in repair of damaged DNA B. inactivation of an oncogene C. repeated exposure to carcinogens D. exposure to radiation E. inactivation of a tumor suppressor gene...
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