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Lec 1 - Intro - INTRODUCTION TO BIO 334 PRINCIPLES OF...

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1 INTRODUCTION TO BIO 334 PRINCIPLES OF NEUROBIOLOGY Toll of Some Major Brain and Nervous System Diseases More Americans are hospitalized with neurological and mental disorders than with any other major disease group, including heart disease and cancer. Disease Number Affected Economic Impact Vision Problems 80,000,000 $51.4B* Alzheimer’s 4,000,000 >$100B** Mental Illness 57,000,000 $317B Stroke 2,000,000 $45B Parkinson’s 500,000 > $3B § *Prevent Blindness America; 2007 numbers **Factsforhealth.org; projecWon from 1991 study Am. J. Psychiatry, 2008 ProjecWon from 1995 numbers § $25B/yr in US, Japan, Germany, France, UK, Spain, Italy combined; 2004 numbers
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2 Neuroscience Experimental – Cognitive • Psychophysics – Behavioral • Neuroethology • Biopsychology – Systems • Physiology/Anatomy – Cellular • Biochemistry • Electrophysiology – Molecular – Computational Clinical – Neurology – Psychiatry/Psychology – Ophthalmology/Audiology – Neuro- • Surgery • Epidemiology • Pharmacology • Pathology • Radiology Biomedical Engineering Hubel Damasio et al. Why Neuroscience? Neuroscience Research Involves All Levels of Analysis in Biological Science Research on Molecules explains how neurons organize themselves. side view top view
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3 Research on Synapses determines how neurons talk to one another. From: Matthews Neurobiology Molecules, Cells and Systems , Blackwell Press Why Neuroscience? Neuroscience Research Involves All Levels of Analysis in Biological Science Research on Neurons determines how these diverse cells function. Why Neuroscience? Neuroscience Research Involves All Levels of Analysis in Biological Science
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4 Mapping research identifies the detailed organization of the brain. Region of olfactory bulb activated by smelling pentanoic acid (red) and phenol (blue). From: Uchida et al., Nat. Neurosci. 3 : 1035-1043, 2000 Why Neuroscience? Neuroscience Research Involves All Levels of Analysis in Biological Science Network analysis determines how neurons interact to produce functioning nervous systems. Network of neurons in olfactory bulb. From: www.apuche.org Why Neuroscience? Neuroscience Research Involves All Levels of Analysis in Biological Science
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5 Systems research investigates localization of function and how brain lesions alter behavior. Individual with Wernicke’s aphasia; answer to the question “You worked in three departments?” Why Neuroscience? Neuroscience Research Involves All Levels of Analysis in Biological Science Dr. Mark F. Bear Dr. Barry W. Connors Dr. Michael A. Paradiso Textbook
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6 Supplemental Texts: Totally Optional Buy used!! Course Outline Jan 24 (Tues) Introduction/Brain Organization (Matthews) Chapters 1,2 Jan 26 (Thurs) Nervous System Structure (Matthews) Chapters 2, 7 Jan 31 (Tues) Neural Development (Matthews) Chapters 7, 23
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7 Course Outline Prior to Lecture 4 , review the recorded lecture on Membrane Potential at
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