Lec 3 - Neural Development

Lec 3 - Neural Development - Developmental perspective on...

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1 Developmental perspective on organization of the nervous system Why do we divide the brain into three major subdivisions (forebrain, midbrain, and hindbrain)? How are the dividing lines between the three divisions set? Why is the forebrain subdivided into the telencephalon and diencephalon? The answers come from the organization of the nervous system very early in its development. human brain is really just .... a folded tube.
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2 Early differentiation of the nervous system in a vertebrate embryo Development of the brain at the anterior end of the neural tube
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3 Development of the telencephalon Developmental expansion of the telencephalon is reflected in the shape of the lateral ventricles Note that the continuity of the ventricles and spinal canal points out the underlying form of the human brain as a contorted tube
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4 Development of the nervous system can be divided into four broad stages 1. Neurogenesis : cells that will ultimately become neurons must divide and proliferate to produce the necessary precursor cells (the cellular raw material of the nervous system) 2. Neuronal migration : the newly produced neurons must move from their birthplace to their appropriate locations within the nervous system 3. Process outgrowth : the cell body of the neuron must grow dendrites to receive inputs from other neurons and an axon to connect with the appropriate targets 4. Synapse formation : after the axon has reached the target, it must recognize the correct target cells and form synaptic connections Neurogenesis: first step is Neuronal Determination Neural induction : nervous system arises during gastrulation from a portion of the ectoderm called the neuroectoderm Mesodermal cells that form the notochord send a
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