Lec 11 - Basal Ganglia and Cerebellum

Lec 11 - Basal Ganglia and Cerebellum - Basal Basal Ganglia...

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Basal Ganglia and Cerebellum Thiws pdf is enabled for commenting in Adobe Reader and the urls are active BIO334 - 2012 raig Evinger Craig Evinger
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Basal Ganglia Anatomy 5 Nuclei : Caudate, Putamen, Globus Pallidus (internal & external), ubthalamic, and Substantia Nigra Subt a a c, a d Substa t a g a (reticulata & compacta) Inputs (corticostriatal) primarily come to the Striatum (Caudate & Putamen)
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Basal Ganglia Anatomy Nucleus Accumbens (Ventral Striatum) Internal Capsule Caudate Ventral Striatum utamen A.K.A. Nucleus ccumbens Putamen Accumbens Nucleus accumbens is the rostral striatum region in humans where the internal capsule does not split the caudate and putamen.
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Basal Ganglia Anatomy 5 Nuclei : Caudate, Putamen, Globus Pallidus (internal & external), ubthalamic, and Substantia Nigra Subt a a c, a d Substa t a g a (reticulata & compacta) BG Inputs (corticostriatal) p () primarily come to the Striatum (Caudate & Putamen) BG Outputs arise from Substantia Nigra reticulata and Globus Pallidus internal and inhibit thalamus and superior colliculus primarily Subthalamic and Globus Pallidus external link inputs and outputs of basal ganglia ubstantia Nigra compacta Substantia Nigra compacta modulates neurons in the striatum with the neurotransmitter dopamine
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Basal Ganglia Interactions with the Cortex The basal ganglia can affect movements by modulating MA and PMA (area 6) in SMA and PMA (area 6) in motor cortex. SMA and PMA modulates MI (area 4) and MI odulates SMA and PMA modulates SMA and PMA The “loop” created by the asal ganglia, thalamus and basal ganglia, thalamus and motor cortex illustrates the interconnections among ovement centers The movement centers. The ‘parallel’ organization for movement. Damage to the basal ganglia can cause reduced ovement ( ypokinesia or movement ( hypokinesia ) or uncontrollable, excessive movement ( hyperkinesia )
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Basal Ganglia Circuit Organization Indirect Pathway Direct Pathway Cerebral Cortex Glu Glu y GABA Enk GABA SP Striatum D1 D2 GABA GPe SNc A GABA Glu STN DA D1, dopamine type 1 receptor; D2, dopamine type 2 receptor; Enk, GPi / SNr Thalamus Inhibitory Excitatory enkephalin; GABA, γ aminobutyric acid; Glu, glutamate; GPe, globus pallidus external; GPi, globus pallidus internal; SNc, substantia nigra pars compacta; SNr, substantia nigra pars reticulata; STN, subthalamic nucleus After Wichmann & Delong, Curr. Opin. Neurosci. 6: 751758, 1996
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Basal Ganglia Circuit Organization Indirect Pathway irect Pathway Inputs are excitatory Outputs are hibitory Cerebral Cortex Glu Glu y Direct Pathway inhibitory Activating striatal neurons in the Direct Pathway Decreases GABA Enk GABA SP Striatum 1 2 basal ganglia inhibition of the thalamus and allows movement to go rward GABA GPe Nc D1 D2 forward Activating striatal neurons in the Indirect Pathway Increases TN SNc DA basal ganglia inhibition of thalamus and blocks movement GABA Glu STN Gpi / SNr Thalamus 1 dopamine type 1 receptor; D2 dopamine type 2 receptor; Enk Inhibitory Excitatory
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This note was uploaded on 04/05/2012 for the course BIO 334 taught by Professor Matthews during the Spring '08 term at SUNY Stony Brook.

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Lec 11 - Basal Ganglia and Cerebellum - Basal Basal Ganglia...

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