Lec 14 - Chemical Senses

Lec 14 - Chemical Senses - Chemical Senses Olfaction...

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1 Chemical Senses • Olfaction – primary receptors in olfactory epithelium – mechanism of transduction – brain pathways for olfactory information • Taste – primary receptors in taste buds – multiple mechanisms of transduction – brain pathways for taste information Olfactory epithelium
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2 Olfactory Receptor Neurons www.ukmn.gwdg.de/source/projects.html Olfactory Receptor Neurons www.ukmn.gwdg.de/source/projects.html
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3 Response to odorants Sensory Transduction in Olfactory Neurons • Odorant is detected by specific receptor molecule • there are >1000 odorant receptor genes in rodents • ~350 odorant receptor genes in humans • Each olfactory cell is thought to express only one type of odorant receptor molecule • Odorant receptors are G-protein-coupled receptors • The G-protein is called G olf G olf activates the synthetic enzyme for cAMP, adenylyl cyclase • cAMP binds to and activates a non-specific cation channel (related to cGMP-gated channel of photoreceptors) • Opening of channel depolarizes cell and allows influx of Ca 2+ • Ca 2+ activates chloride channels • Because E Cl is positive to the resting potential in olfactory sensory neurons, Cl - flows out of the cell, reinforcing depolarization
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4 Sensory Transduction in Olfactory Neurons Adaptation in Olfactory Receptor Neurons www.fz-juelich.de/ibi/ibi-1/index.php?path=Chemosensation&index=145&print=1
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