Lec 14 - Chemical Senses

Lec 14 - Chemical Senses - 1 Chemical Senses Olfaction...

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Unformatted text preview: 1 Chemical Senses Olfaction primary receptors in olfactory epithelium mechanism of transduction brain pathways for olfactory information Taste primary receptors in taste buds multiple mechanisms of transduction brain pathways for taste information Olfactory epithelium 2 Olfactory Receptor Neurons www.ukmn.gwdg.de/source/projects.html Olfactory Receptor Neurons www.ukmn.gwdg.de/source/projects.html 2 Olfactory Receptor Neurons www.ukmn.gwdg.de/source/projects.html Olfactory Receptor Neurons www.ukmn.gwdg.de/source/projects.html 3 Response to odorants Sensory Transduction in Olfactory Neurons Odorant is detected by specifc receptor molecule there are >1000 odorant receptor genes in rodents ~350 odorant receptor genes in humans Each olFactory cell is thought to express only one type oF odorant receptor molecule Odorant receptors are G-protein-coupled receptors The G-protein is called G olF G olF activates the synthetic enzyme For cAMP, adenylyl cyclase cAMP binds to and activates a non-specifc cation channel (related to cGMP-gated channel oF photoreceptors) Opening oF channel depolarizes cell and allows inux oF Ca 2+ Ca 2+ activates chloride channels Because E Cl is positive to the resting potential in olFactory sensory neurons, Cl- ows out oF the cell, reinForcing depolarization 4 Sensory Transduction in Olfactory Neurons Adaptation in Olfactory Receptor Neurons www.fz-juelich.de/ibi/ibi-1/index.php?path=Chemosensation&index=145&print=1 5...
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Lec 14 - Chemical Senses - 1 Chemical Senses Olfaction...

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