Lec 14 - Chemical Senses

Lec 14 - Chemical Senses - 1 Chemical Senses • Olfaction...

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Unformatted text preview: 1 Chemical Senses • Olfaction – primary receptors in olfactory epithelium – mechanism of transduction – brain pathways for olfactory information • Taste – primary receptors in taste buds – multiple mechanisms of transduction – brain pathways for taste information Olfactory epithelium 2 Olfactory Receptor Neurons www.ukmn.gwdg.de/source/projects.html Olfactory Receptor Neurons www.ukmn.gwdg.de/source/projects.html 2 Olfactory Receptor Neurons www.ukmn.gwdg.de/source/projects.html Olfactory Receptor Neurons www.ukmn.gwdg.de/source/projects.html 3 Response to odorants Sensory Transduction in Olfactory Neurons • Odorant is detected by specifc receptor molecule • there are >1000 odorant receptor genes in rodents • ~350 odorant receptor genes in humans • Each olFactory cell is thought to express only one type oF odorant receptor molecule • Odorant receptors are G-protein-coupled receptors • The G-protein is called G olF • G olF activates the synthetic enzyme For cAMP, adenylyl cyclase • cAMP binds to and activates a non-specifc cation channel (related to cGMP-gated channel oF photoreceptors) • Opening oF channel depolarizes cell and allows in¡ux oF Ca 2+ • Ca 2+ activates chloride channels • Because E Cl is positive to the resting potential in olFactory sensory neurons, Cl- ¡ows out oF the cell, reinForcing depolarization 4 Sensory Transduction in Olfactory Neurons Adaptation in Olfactory Receptor Neurons www.fz-juelich.de/ibi/ibi-1/index.php?path=Chemosensation&index=145&print=1 5...
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This note was uploaded on 04/05/2012 for the course BIO 334 taught by Professor Matthews during the Spring '08 term at SUNY Stony Brook.

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Lec 14 - Chemical Senses - 1 Chemical Senses • Olfaction...

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