Disorders - DISORDERS OF THE IMMUNE SYSTEM Autoimmune Diseases A Develop immunity to self-Ag on host tissues autoantibodies T lymphocytes B

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DISORDERS OF THE IMMUNE SYSTEM Autoimmune Diseases A. Develop immunity to “self”-Ag. on host tissues autoantibodies, T lymphocytes B. Development autoimmunity destruction host tissues C. Immunological tolerance - ability to recognize “self” vs “non-self.” D. Due to: 1. Clonal deletion a. Develops during prenatal period. b. B lymphocytes with immune receptors to “self” Ag. destroyed c. Do not develop immunity to host tissues. 2. T S lymph prevents development of immunity to “self” Ag. Possible Causes of Autoimmunity 1. Genetic predisposition - due to faulty gene a. Direct cause b. Makes individual more susceptible to other causes 2. Altered self-ag. a. Mutations – cause changes in structure host cells b. Self-Ag. altered or new Ag. inserted into host cell membranes (viruses, drugs, chemicals) c. No longer recognized as self auto antibodies 3. Cross reactions a. Ab. developed against hapten or whole Ag. b. Ab. also reacts with self-Ag. (cross reaction) c. Ex. Streptococcus pyogenes - rheumatic fever 4. Release of hidden or sequestered Ag. a.
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This note was uploaded on 04/05/2012 for the course MCB MCB2010 taught by Professor Smith during the Spring '09 term at Broward College.

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Disorders - DISORDERS OF THE IMMUNE SYSTEM Autoimmune Diseases A Develop immunity to self-Ag on host tissues autoantibodies T lymphocytes B

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