Type II - Type II - Cytotoxic reactions a. Due to: 1). 2)....

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Type II - Cytotoxic reactions a. Due to: 1). IgG, IgM – complement fixing antibodies 2). Complement system 3). Allergen – whole (intact) cells b. Primary exposure: 1). Cellular allergen IgG or IgM 2). Sensitized c. Subsequent exposure: 1). Cell allergen + IgG (IgM) Cell Ag. – Ab. complex 2). Cell Ag. – Ab. complex + Complement Lysis cells, Inflammation d. Ex.: autoimmune diseases, transfusion reactions, Rh incompatibility, hemolytic disease of the newborn 5. Type III - Immune complex reactions a. Due to: 1). IgG, IgM – complement fixing antibodies 2). Complement system 3). Allergen - soluble antigen b. Primary exposure: 1). Soluble allergen IgG, (IgM) 2). Sensitized c. Subsequent exposure 1). Soluble allergen + IgG (IgM) Soluble Ag. – Ab. complex 2). Soluble Ag. – Ab. complex + Complement Lysis host cells, inflamation d. Types of reactions 1). Atopic reaction – Arthus reaction a). Localized tissue damage b). Ex. soluble allergen – tetanus toxoid booster
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This note was uploaded on 04/05/2012 for the course MCB MCB2010 taught by Professor Smith during the Spring '09 term at Broward College.

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Type II - Type II - Cytotoxic reactions a. Due to: 1). 2)....

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