Lecture 1 - Prof Simpson Joseph 4102 Urey Hall Oce Hours...

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Prof. Simpson Joseph 4102 Urey Hall Office Hours: Friday 2:00 to 4:00 PM http://josephgroup.ucsd.edu/Simpson_Joseph_Group/Welcome.html
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Kaitlin Mallory ( [email protected] ) A01, 02, 03 John Zuris ( [email protected] ) A04, 05, 06
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Midterm 1 (25%): April 24 th Midterm 2 (25%): May 22 nd Final Exam (50%): June 12 th Bonus Points (up to 5%)
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How do cells replicate DNA? How do cells use the information in DNA to make proteins? http://youtu.be/ZZPvPLazf_g
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DNA is the Blueprint of Life
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DNA RNA Protein Many Transcription Factors control the expression of genes. Example: Zinc-finger proteins Central Dogma of Molecular Biology
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DNA is a polymer DNA is made up of: (1) Base (2) Sugar (3) Phosphate group
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Sugar
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Phosphate Group
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BASES
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Electron micrograph of E. coli genome E. coli genome = 4.6 million base pairs Human genome = 6 billion base pairs
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Early Breakthroughs in Nucleic Acids Research 1869 Fritz Miescher discovers that the nuclei of pus cells contains an acidic substance to which he gave the name ‘nuclein’.
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